| Rank | Student | Grade | School | Year | | M | TD |
| 1 | Karson Hill | Sr | Trenton | 2011-2012 | | 46 | 559 |
| 2 | T.J. Hill | Sr | Farmington | 1997-1998 | | 43 | 387 |
| 3 | Jeramiah Warren Smith | Sr | Summit Christian Academy | 2022-2023 | | 52 | 366 |
| 4 | Kyler James Rea | Sr | Neosho | 2015-2016 | | 58 | 364 |
| 5 | Gary Lindsay | Jr | Brookfield | 2009-2010 | | 51 | 346 |
| 6 | James Anding | Sr | Pacific | 2018-2019 | | 51 | 334 |
| 7 | Curtis Bledsoe | Sr | Hazelwood East | 1999-2000 | | 38 | 329 |
| 8 | Rodney Pettit | Sr | Belton | 2002-2003 | | 42 | 311 |
| 9 | Brian Roskin | Sr | MICDS | 1999-2000 | | 43 | 301 |
| 10 | Jerome Frazier | Sr | Lincoln College Prep | 1993-1994 | | 42 | 295 |
| 11 | Wyatt Pickering | Sr | Chillicothe | 1998-1999 | | 41 | 294 |
| 12 | Jon Ott | Sr | DeSmet | 2000-2001 | | 42 | 284 |
| 13 | Kyle Newham | | Richmond | 1996-1997 | | 40 | 262 |
| 14 | Cevion Jordan Severado | Jr | Christian Brothers College | 2016-2017 | | 49 | 247 |
| 15 | Jake Hunter | Jr | Harrisonville | 2006-2007 | | 49 | 235 |
| 16 | Bryce Newham | Fr | Boonville | 2024-2025 | | 51 | 206 |
| 17 | Leo Theodore Buchheit | Sr | North Point | 2024-2025 | | 48 | 169 |
| 18 | | Jr | Lebanon | 2018-2019 | | 54 | 153 |
| 18 | Trevor Christian | Jr | Lebanon | 2018-2019 | | 54 | 153 |
| 20 | Kailey Michelle Benson | Sr | Francis Howell Central | 2024-2025 | 6 were forfeits | 48 | 138 |
| 21 | Kailey Michelle Benson | Jr | Francis Howell Central | 2023-2024 | | 45 | 113 |
| 22 | Jaycee Foeller | Jr | DeSoto | 2019-2020 | | 46 | 66 |
| 23 | Jessa Joiner | Fr | Lebanon | 2021-2022 | | 46 | 64 |
| 24 | Kaylyn Rogers | Sr | Lebanon | 2021-2022 | | 46 | 61 |
| 25 | Bailey Joiner | Jr | Lebanon | 2021-2022 | | 39 | 52 |
| 26 | Jaycee Foeller | So | DeSoto | 2018-2019 | | 35 | 51 |
| 26 | Jaycee Foeller | Sr | DeSoto | 2020-2021 | | 39 | 51 |