| Rank | Time | Student | School | Date | |
| 1 | 1:47.25 | Taylor Wohrley | Timberland | 2/20/2009 | |
| 2 | 1:48.63 | Avery Michelle TRUE | Liberty North | 2/17/2024 | |
| 3 | 1:49.37 | Kelley Tackett | Rock Bridge | 2/20/2016 | |
| 4 | 1:49.44 | Anna Moehn | Cor Jesu Academy | 2/19/2022 | |
| 5 | 1:49.46 | Kelley Tackett | Rock Bridge | 2/16/2013 | |
| 6 | 1:49.53 | Avery Michelle TRUE | Liberty North | 2/17/2024 | |
| 7 | 1:49.93 | Kelley Tackett | Rock Bridge | 2/22/2014 | |
| 8 | 1:50.06 | Macie M Beairsto | Glendale | 2/20/2016 | |
| 9 | 1:50.28 | Macey Hansen | Battle | 2/17/2024 | |
| 10 | 1:50.29 | Macie M Beairsto | Glendale | 2/21/2015 | |
| 11 | 1:50.32 | Taylor Wohrley | Timberland | 2/16/2008 | |
| 12 | 1:50.37 | Hannah Kinder | Central (Cape Girardeau) | 2/17/2007 | |
| 12 | 1:50.37 | Franceska Patricia Petrosino | Lafayette (Wildwood) | 2/17/2018 | Class 2 |
| 14 | 1:50.40 | Jenna Harris | Webster Groves | 5/20/2006 | |
| 15 | 1:50.65 | Anna-Grace G Guenther | St. Joseph's Academy | 2/22/2025 | |
| 16 | 1:50.75 | Paige Riekhof | Park Hill South | 2/17/2018 | Class 2 |
| 17 | 1:50.83 | Alexis Lynn Cook | Parkway South | 2/20/2025 | |
| 18 | 1:50.96 | Alexis Lynn Cook | Parkway South | 2/21/2025 | |
| 19 | 1:51.01 | Ellie Wehrmann | Incarnate Word Academy | 2/16/2018 | |
| 20 | 1:52.50 | Grace Beahan | Hickman | 2/17/2018 | Class 2 |
| 21 | 1:52.80 | Allison Weber | Marshall | 2/16/2018 | Class 1 |
| 22 | 1:53.84 | Ansley Barnes | Rock Bridge | 2/16/2018 | Class 2 |
| 23 | 1:53.88 | Maria Louise Newton | Parkway West | 2/16/2018 | |
| 24 | 1:53.97 | Catherine Elizabeth Behl | Lafayette (Wildwood) | 2/16/2018 | Class 2 |
| 25 | 1:53.98 | Parker E Hagemann | Webster Groves | 2/15/2018 | Class 1 |
| 26 | 1:57.12 | Sarah Jane Bonnett | Parkway West | 2/15/2018 | Class 1 |