| Rank | Pts | Student | School | Opponent | Date | |
| 1 | 217 | | Bronaugh | Schell City | 2/4/1951 | |
| 1 | 217 | | Bronaugh | Schell City | 2/7/1951 | |
| 3 | 212 | | Bronaugh | Schell City | 12/14/1950 | |
| 4 | 204 | | North County | Fredericktown | 3/4/1994 | 103-91 |
| 5 | 197 | | Schell City | Preston | 1/20/1951 | 101-96 |
| 6 | 184 | | Bolivar | Buffalo | 2/8/2016 | 98-86 |
| 7 | 182 | | Bronaugh | Schell City | 12/1/1950 | 92-90 |
| 8 | 181 | | Southern Boone | Armstrong | 2/4/1966 | 96-85 |
| 9 | 180 | | Central (New Madrid County) | Scott County Central | 1/3/1994 | 97-83 |
| 9 | 180 | | Verona | Miller | 1/23/2010 | 96-84 |
| 11 | 176 | | Bronaugh | Metz | 12/15/1950 | 121-55 |
| 12 | 169 | | Maryville | Glenwood, IA | 1/16/2021 | |