| Rank | Student | School | Opponent | Date | | Q | Pts |
| 1 | | Stoutland | Iberia | 1/12/2004 | | 1 | 49 |
| 1 | | Meadville | Bevier | 1/10/2023 | | 1 | 49 |
| 3 | | Kelly | Twin Rivers | 1/19/1978 | 46-4 | 2 | 46 |
| 3 | | South Iron | Bismarck | 11/30/2019 | | 1 | 46 |
| 3 | | Delta | Charleston | 1/22/2022 | | 3 | 46 |
| 6 | | Scott County Central | Woodland | 2/7/1985 | | 2 | 45 |
| 6 | | Meadville | Hale | 1/23/2023 | | 1 | 45 |
| 8 | | Scott County Central | Delta | 1/20/1986 | | 1 | 44 |
| 8 | | Jefferson (Conception) | Osborn | 12/22/1988 | | 1 | 44 |
| 8 | | Macks Creek | Skyline | 12/19/2002 | | 4 | 44 |
| 11 | | Paris | Sturgeon | 12/2/1978 | | 1 | 43 |
| 11 | | Polo | Breckenridge | 12/18/1980 | | 3 | 43 |
| 13 | | Troy Buchanan | Winfield | 11/20/1984 | | 2 | 42 |
| 13 | | Scott County Central | East Prairie | 1/9/1986 | | 1 | 42 |
| 13 | | Neelyville | Puxico | 2/8/2025 | | 1 | 42 |
| 16 | | Southern Boone | Versailles | 12/1/2016 | | 1 | 38 |
| 17 | | Southern Boone | Versailles | 1/20/2014 | | 1 | 37 |
| 18 | | Southern Boone | Versailles | 1/2/2016 | | 1 | 36 |
| 19 | | Southern Boone | Versailles | 12/30/2016 | | 2 | 35 |
| 20 | | Southern Boone | Versailles | 1/15/2019 | | 1 | 33 |
| 21 | | Scott County Central | Gainesville | 3/1/1982 | | 1 | 32 |
| 21 | | Scott County Central | Gainesville | 3/1/1982 | | 1 | 32 |
| 21 | | Climax Springs | Couch | 3/1/2001 | | 3 | 32 |
| 21 | | Climax Springs | Couch | 3/1/2001 | | 3 | 32 |
| 21 | | Lathrop | Van Horn | 1/12/2011 | | 1 | 32 |
| 26 | | Southern Boone | South Callaway | 2/1/2005 | | 3 | 31 |
| 26 | | Hartville | Fair Grove | 1/7/2021 | | 4 | 31 |
| 26 | | Southern Boone | St. Clair | 1/10/2022 | | 1 | 31 |
| 29 | | Scott County Central | Rich Hill | 3/1/1992 | | 3 | 30 |
| 29 | | Scott County Central | Rich Hill | 3/1/1992 | | 3 | 30 |
| 29 | | South Nodaway | Meadville | 3/1/1995 | | 4 | 30 |
| 29 | | South Nodaway | Meadville | 3/1/1995 | | 4 | 30 |
| 29 | | Southern Boone | Boonville | 2/15/2024 | | 4 | 30 |
| 29 | | Lift for Life Academy Charter | Central (Park Hills) | 3/14/2024 | | 3 | 30 |
| 35 | | Gainesville | Scott County Central | 3/1/1982 | | 4 | 29 |
| 35 | | Gainesville | Scott County Central | 3/1/1982 | | 4 | 29 |
| 35 | | Festus | Central (KC) | 3/1/1988 | | 4 | 29 |
| 35 | | Festus | Central (Kansas City) | 3/1/1988 | | 4 | 29 |
| 35 | | Holden | Monroe City | 3/1/1988 | | 2 | 29 |
| 35 | | Holden | Monroe City | 3/1/1988 | | 2 | 29 |
| 35 | | New Bloomfield | Scott County Central | 3/1/1988 | | 1 | 29 |
| 35 | | New Bloomfield | Scott County Central | 3/1/1988 | | 1 | 29 |
| 35 | | Oak Grove | Fredericktown | 3/1/1990 | | 2 | 29 |
| 35 | | Oak Grove | Fredericktown | 3/1/1990 | | 2 | 29 |
| 35 | | Scott County Central | New Bloomfield | 3/1/1991 | | 3 | 29 |
| 35 | | Scott County Central | New Bloomfield | 3/1/1991 | | 3 | 29 |
| 35 | | Lathrop | Lexington | 11/26/2013 | | 1 | 29 |
| 35 | | Incarnate Word Academy | Staley | 3/1/2021 | | 1 | 29 |
| 35 | | Lathrop | Penney | 1/22/2024 | | 1 | 29 |
| 35 | | Lathrop | Braymer | 1/21/2025 | | 2 | 29 |