| Rank | Student | Grade | School | Year | | RB | G | PerG |
| 1 | Brandi Moore | Sr | Berkeley High School | 1997-1998 | | 438 | 21 | 20.86 |
| 2 | Casey Covington | Jr | Pattonville | 1988-1989 | | 541 | 28 | 19.32 |
| 3 | Barb Paul | Sr | Stet High School | 1980-1981 | | 422 | 22 | 19.18 |
| 4 | Erin Ivie | Jr | Niangua | 1996-1997 | | 472 | 25 | 18.88 |
| 5 | Kay Schultehenrich | Sr | Duchesne | 1979-1980 | | 533 | 29 | 18.38 |
| 6 | Tina Dixon | Jr | Paseo (Kansas City) High School | 1980-1981 | | 456 | 25 | 18.24 |
| 7 | Casey Covington | Sr | Pattonville | 1989-1990 | | 489 | 27 | 18.11 |
| 8 | Janet Peasel | Sr | Silex | 1980-1981 | | 408 | 23 | 17.74 |
| 9 | Stacy Primus | Jr | North Callaway | 1985-1986 | | 422 | 24 | 17.58 |
| 10 | Kim Scammon | Jr | Rock Port | 1980-1981 | | 414 | 24 | 17.25 |
| 11 | Erin Ivie | Sr | Niangua | 1997-1998 | | 446 | 26 | 17.15 |
| 12 | Carrie Rager | So | Palmyra | 1990-1991 | | 536 | 32 | 16.75 |
| 13 | Paige Tate | Sr | Spokane | 2019-2020 | | 435 | 26 | 16.73 |
| 14 | Denise Toney | Sr | Kearney | 1974-1975 | | 451 | 27 | 16.70 |
| 15 | Kylee Richey | Fr | Versailles | 2021-2022 | | 400 | 24 | 16.67 |
| 16 | Christie Cox | Sr | Warsaw | 1984-1985 | | 448 | 27 | 16.59 |
| 17 | Cassy Felkerson | Sr | Salem | 1997-1998 | | 450 | 28 | 16.07 |
| 18 | Brenna Couch | Sr | Plato | 2023-2024 | | 315 | 21 | 15.00 |
| 19 | Abbi Fountain | Sr | Novinger | 2022-2023 | | 392 | 28 | 14.00 |
| 20 | Brenna Couch | Jr | Plato | 2022-2023 | | 341 | 26 | 13.12 |
| 21 | Ashton Bailey Judd | Sr | West Plains | 2021-2022 | | 356 | 31 | 11.48 |
| 22 | Ashton Bailey Judd | Jr | West Plains | 2020-2021 | | 344 | 32 | 10.75 |
| 23 | Enzley Dinkins | Sr | South Iron | 2023-2024 | | 299 | 28 | 10.68 |