| Rank | Student | Grade | School | Year | | G | RB |
| 1 | Casey Covington | Jr | Pattonville | 1988-1989 | | 28 | 541 |
| 2 | Carrie Rager | So | Palmyra | 1990-1991 | | 32 | 536 |
| 3 | Kay Schultehenrich | Sr | Duchesne | 1979-1980 | | 29 | 533 |
| 4 | Cassey Covington | Sr | Pattonville | 1989-1990 | | 27 | 489 |
| 5 | Erin Ivie | Jr | Niangua | 1996-1997 | | 25 | 472 |
| 6 | Tina Dixon | Jr | Paseo (Kansas City) High School | 1980-1981 | | 25 | 456 |
| 7 | Denise Toney | Sr | Kearney | 1974-1975 | | 27 | 451 |
| 8 | Cassy Felkerson | Sr | Salem | 1997-1998 | | 28 | 450 |
| 9 | Christie Cox | Sr | Warsaw | 1984-1985 | | 27 | 448 |
| 10 | Erin Ivie | Sr | Niangua | 1997-1998 | | 26 | 446 |
| 11 | Brandi Moore | Sr | Berkeley High School | 1997-1998 | | 21 | 438 |
| 12 | Paige Tate | Sr | Spokane | 2019-2020 | | 26 | 435 |
| 13 | Barb Paul | Sr | Stet High School | 1980-1981 | | 22 | 422 |
| 13 | Stacy Primus | Jr | North Callaway | 1985-1986 | | 24 | 422 |
| 15 | Kim Scammon | Jr | Rock Port | 1980-1981 | | 24 | 414 |
| 16 | Janet Peasel | Sr | Silex | 1980-1981 | | 23 | 408 |
| 17 | Kylee Richey | Fr | Versailles | 2021-2022 | | 24 | 400 |
| 18 | Abbi Fountain | Sr | Novinger | 2022-2023 | | 28 | 392 |
| 19 | Ashton Bailey Judd | Sr | West Plains | 2021-2022 | | 31 | 356 |
| 20 | Ashton Bailey Judd | Jr | West Plains | 2020-2021 | | 32 | 344 |
| 21 | Brenna Couch | Jr | Plato | 2022-2023 | | 26 | 341 |
| 22 | Brenna Couch | Sr | Plato | 2023-2024 | | 21 | 315 |