| Rank | Student | School | Year | | AST | G | PerG |
| 1 | | Van-Far | 2003-2004 | | 771 | 31 | 24.87 |
| 2 | | Notre Dame (Cape Girardeau) | 1986-1987 | | 794 | 34 | 23.35 |
| 3 | | Chadwick | 2003-2004 | | 578 | 26 | 22.23 |
| 4 | | Delta | 2019-2020 | | 685 | 31 | 22.10 |
| 5 | | La Plata | 2010-2011 | | 652 | 31 | 21.03 |
| 6 | | Westminster Christian Academy | 1987-1988 | | 518 | 25 | 20.72 |
| 7 | | La Plata | 2006-2007 | | 632 | 31 | 20.39 |
| 8 | | Lathrop | 1999-2000 | | 505 | 25 | 20.20 |
| 9 | | Risco | 2011-2012 | | 557 | 28 | 19.89 |
| 10 | | Dexter | 2000-2001 | | 551 | 28 | 19.68 |
| 11 | | Lathrop | 2000-2001 | | 491 | 25 | 19.64 |
| 12 | | Warrensburg | 2003-2004 | | 548 | 28 | 19.57 |
| 13 | | La Plata | 2007-2008 | | 576 | 30 | 19.20 |
| 14 | | Chillicothe | 1997-1998 | | 607 | 32 | 18.97 |
| 15 | | Versailles | 2021-2022 | | 534 | 29 | 18.41 |
| 16 | | North Shelby | 2004-2005 | | 560 | 32 | 17.50 |