| Rank | Student | School | Year | | G | AST |
| 1 | | Notre Dame (Cape Girardeau) | 1986-1987 | | 34 | 794 |
| 2 | | Van-Far | 2003-2004 | | 31 | 771 |
| 3 | | Delta | 2019-2020 | | 31 | 685 |
| 4 | | La Plata | 2010-2011 | | 31 | 652 |
| 5 | | La Plata | 2006-2007 | | 31 | 632 |
| 6 | | Chillicothe | 1997-1998 | | 32 | 607 |
| 7 | | Chadwick | 2003-2004 | | 26 | 578 |
| 8 | | La Plata | 2007-2008 | | 30 | 576 |
| 9 | | North Shelby | 2004-2005 | | 32 | 560 |
| 10 | | Risco | 2011-2012 | | 28 | 557 |
| 11 | | Dexter | 2000-2001 | | 28 | 551 |
| 12 | | Warrensburg | 2003-2004 | | 28 | 548 |
| 13 | | Versailles | 2021-2022 | | 29 | 534 |
| 14 | | Westminster Christian Academy | 1987-1988 | | 25 | 518 |
| 15 | | Lathrop | 1999-2000 | | 25 | 505 |
| 16 | | Lathrop | 2000-2001 | | 25 | 491 |