| Rank | School | Year | | RB | G | Total |
| 1 | Plato | 1975-1976 | | 1638 | 34 | 48.18 |
| 2 | Putnam County | 1975-1976 | | 1309 | 29 | 45.14 |
| 3 | Notre Dame (Cape Girardeau) | 1986-1987 | | 1505 | 34 | 44.26 |
| 4 | Stanberry | 1976-1977 | | 1038 | 24 | 43.25 |
| 5 | Stanberry | 1970-1971 | | 1333 | 31 | 43.00 |
| 5 | Stanberry | 1971-1972 | | 1075 | 25 | 43.00 |
| 7 | Stanberry | 1975-1976 | | 980 | 23 | 42.61 |
| 8 | Hallsville | 1980-1981 | | 1293 | 31 | 41.71 |
| 9 | Bell City | 2002-2003 | | 1238 | 30 | 41.27 |
| 10 | Versailles | 2021-2022 | | 1187 | 29 | 40.93 |
| 11 | Lafayette County | 1987-1988 | | 1200 | 30 | 40.00 |
| 12 | Van-Far | 2003-2004 | | 1236 | 31 | 39.87 |
| 13 | Chillicothe | 1995-1996 | | 1225 | 32 | 38.28 |
| 14 | Risco | 2017-2018 | | 1047 | 28 | 37.39 |
| 15 | Whitfield | 1999-2000 | | 1221 | 33 | 37.00 |
| 16 | Risco | 2012-2013 | | 1056 | 29 | 36.41 |
| 17 | Delta | 2019-2020 | | 1101 | 31 | 35.52 |