| Rank | Student | School | Year | | G | RB |
| 1 | | Plato | 1975-1976 | | 34 | 1638 |
| 2 | | Notre Dame (Cape Girardeau) | 1986-1987 | | 34 | 1505 |
| 3 | | Bell City | 2001-2002 | | 34 | 1341 |
| 4 | | Stanberry | 1970-1971 | | 31 | 1333 |
| 5 | | Putnam County | 1975-1976 | | 29 | 1309 |
| 6 | | Hallsville | 1980-1981 | | 31 | 1293 |
| 7 | | Bell City | 2002-2003 | | 30 | 1238 |
| 8 | | Van-Far | 2003-2004 | | 31 | 1236 |
| 9 | | Chillicothe | 1995-1996 | | 32 | 1225 |
| 10 | | Whitfield | 1999-2000 | | 33 | 1221 |
| 11 | | Lafayette County | 1987-1988 | | 30 | 1200 |
| 12 | | Versailles | 2021-2022 | | 29 | 1187 |
| 13 | | Delta | 2019-2020 | | 31 | 1101 |
| 14 | | Stanberry | 1971-1972 | | 25 | 1075 |
| 15 | | Northwestern (Mendon) | 2022-2023 | | 26 | 1059 |
| 16 | | Risco | 2012-2013 | | 29 | 1056 |
| 17 | | Risco | 2017-2018 | | 28 | 1047 |
| 18 | | Stanberry | 1976-1977 | | 24 | 1038 |
| 19 | | Stanberry | 1975-1976 | | 23 | 980 |