| Rank | BLK | Student | School | Opponent | Date | |
| 1 | 21 | | Scott City | Hayti | 1/30/2004 | |
| 1 | 21 | | Brunswick | Keytesville | 2/9/2018 | |
| 3 | 20 | | Lutheran St. Charles | Monroe City | 2/28/2002 | at Clopton |
| 4 | 18 | | North Shelby | Linn County | 11/23/2004 | |
| 5 | 17 | | Marshfield | Versailles | 11/30/1999 | at Buffalo |
| 5 | 17 | | North Shelby | Brashear | 2/22/2005 | |
| 7 | 16 | | North Shelby | Atlanta | 1/22/1998 | |
| 7 | 16 | | North Shelby | Northeast (Cairo) | 1/13/2005 | |
| 9 | 15 | | St. Louis University | DeSmet | 2/10/1995 | |
| 9 | 15 | | North Shelby | Milan | 12/4/2004 | |
| 9 | 15 | | North Shelby | Bevier | 12/9/2004 | |
| 9 | 15 | | North Shelby | Centralia | 1/3/2005 | |
| 13 | 14 | | Fairfax | Clopton | 3/1/1989 | |
| 13 | 14 | | Fairfax | Clopton | 1/1/1989 | |
| 15 | 12 | | Notre Dame (Cape Girardeau) | Ste. Genevieve | 2/22/2021 | |
| 15 | 12 | | Notre Dame (Cape Girardeau) | Kennett | 1/15/2021 | |
| 17 | 11 | | Soldan International Studies | Willow Springs | 3/1/1990 | |
| 17 | 11 | | Soldan International Studies | Willow Springs | 11/1/1990 | |
| 17 | 11 | | North Callaway | Hollister | 3/1/1999 | |
| 17 | 11 | | North Callaway | Hollister | 1/1/1999 | |
| 17 | 11 | | Westport | Nixa | 3/1/2002 | |
| 17 | 11 | | Westport | Nixa | 1/1/2002 | |
| 23 | 10 | | Eugene | Hartville | 3/1/1992 | |
| 23 | 10 | | Eugene | Hartville | 1/1/1992 | |
| 23 | 10 | | Blair Oaks | Butler | 3/1/2001 | |
| 23 | 10 | | Blair Oaks | Butler | 1/1/2001 | |
| 23 | 10 | | Jefferson (Conception) | Bell City | 3/1/2007 | |
| 23 | 10 | | Jefferson (Conception) | Bell City | 1/1/2007 | |
| 23 | 10 | | Notre Dame (Cape Girardeau) | Central (New Madrid County) | 12/17/2019 | |
| 23 | 10 | | Notre Dame (Cape Girardeau) | Poplar Bluff | 2/14/2020 | |