| Rank | RB | Student | School | Opponent | Date | |
| 1 | 89 | | Gallatin | Worth County | 1/26/1971 | |
| 2 | 83 | | Gallatin | Gilman City | 1/5/1971 | |
| 3 | 81 | | Gallatin | Worth County | 1/24/1972 | |
| 3 | 81 | | Van Horn (Independence) | Winnetonka | 12/3/1982 | |
| 5 | 80 | | Holcomb | Delta (Deering) | 1/15/2019 | |
| 6 | 78 | | Gallatin | Princeton | 12/11/1970 | |
| 7 | 76 | | Gallatin | King City | 1/8/1971 | |
| 8 | 74 | | Twin Rivers | Naylor | 11/28/1978 | |
| 8 | 74 | | Montgomery County | Van-Far | 1/17/1978 | |
| 10 | 72 | | Centralia | Monroe City | 2/13/1979 | |
| 11 | 69 | | Gallatin | La Plata | 3/1/1971 | |
| 11 | 69 | | Gallatin | Polo | 1/15/1972 | |
| 13 | 68 | | Scott County Central | Drexel | 3/1/1976 | |
| 13 | 68 | | Scott County Central | Drexel | 1/1/1976 | |
| 15 | 63 | | Lindbergh | Augustinian Academy | 3/1/1966 | |
| 15 | 63 | | Lindbergh | Augustinian Academy (St. Louis) | 1/1/1966 | |
| 15 | 63 | | Maplewood-Richmond Hts. | Liberty (Mountain View) | 3/1/1988 | |
| 15 | 63 | | Maplewood-Richmond Hts. | Liberty (Mountain View) | 1/1/1988 | |
| 19 | 61 | | Scott County Central | Walnut Grove | 3/1/1988 | |
| 19 | 61 | | Scott County Central | Walnut Grove | 1/1/1988 | |
| 21 | 60 | | Scott County Central | Green City | 3/1/1993 | |
| 21 | 60 | | Scott County Central | Green City | 1/1/1993 | |