| Rank | Pts | Student | School | Opponent | Date | |
| 1 | 172 | | Dixon | Stoutland | 12/2/1968 | 172 - 34 |
| 2 | 166 | | Clearwater | Zalma (52) | 1/15/1980 | |
| 2 | 166 | | Central (St. Louis) | Visual & Performing Arts | 12/10/1980 | 166-57 |
| 4 | 160 | | Tuscumbia | Bland | 2/9/1974 | |
| 5 | 156 | | Winona | Dora | 1/14/1969 | |
| 6 | 150 | | Dixon | Richland | 11/8/1968 | |
| 7 | 148 | | Puxico | Greenville | 2/20/1951 | (at Piedmont) |
| 7 | 148 | | Bernie | Cooter | 11/30/1992 | |
| 9 | 147 | | Elsberry | O'Fallon (Ill.) | 2/23/1953 | |
| 9 | 147 | | Bernie | North Pemiscot | 11/22/1991 | |
| 11 | 126 | | Scott City | Egyptian, IL | 12/9/1997 | |
| 12 | 117 | | Versailles | Eugene | 11/24/2020 | |
| 13 | 114 | | Eugene | Tuscumbia | 2/8/2002 | |
| 14 | 112 | | Glendale | Central (Springfield) | 2/21/2017 | |
| 14 | 112 | | Eugene | Calvary Lutheran | 2/2/2021 | |
| 16 | 111 | | Green City | Linn County | 2/11/2025 | |
| 17 | 110 | | Glendale | West Plains | 1/31/2017 | |
| 18 | 109 | | Macks Creek | Tuscumbia | 12/6/2019 | |
| 18 | 109 | | Versailles | Hallsville | 2/8/2022 | |
| 20 | 108 | | Versailles | Moberly | 12/10/2021 | |
| 21 | 107 | | Versailles | Warsaw | 2/9/2022 | |
| 22 | 106 | | Higbee | Keytesville | 11/30/2021 | |
| 23 | 104 | | Glendale | Branson | 1/19/2018 | |
| 24 | 103 | | Versailles | Richland | 1/25/2022 | |
| 25 | 102 | | St. Francis Borgia | Marshall | 3/1/1993 | |
| 25 | 102 | | Glendale | Greenwood, AR | 12/14/2017 | |
| 27 | 101 | | Glendale | Rolla | 2/17/2017 | |
| 27 | 101 | | Versailles | California | 12/3/2020 | |
| 27 | 101 | | Versailles | Vienna | 1/22/2022 | |
| 30 | 100 | | Scott County Central | Pattonsburg | 3/1/1990 | |
| 31 | 99 | | Webster Groves | Marshall | 3/1/1953 | |
| 31 | 99 | | Mexico | St. Francis Borgia | 3/1/1995 | |
| 31 | 99 | | Versailles | Southern Boone | 12/2/2021 | |
| 34 | 98 | | Scott County Central | Newtown-Harris | 3/1/2009 | |
| 34 | 98 | | Scott City | South Pemiscot | 1/4/2011 | |
| 36 | 97 | | Memorial (Joplin) | McKinley Classical Leadership | 3/1/1978 | |
| 36 | 97 | | Glendale | Ft. Zumwalt South | 1/4/2018 | |
| 38 | 96 | | Glendale | Joplin | 2/14/2017 | |
| 38 | 96 | | Glendale | Venus, TX | 12/9/2022 | |
| 40 | 95 | | Nixa | Lilbourn | 3/1/1978 | |
| 40 | 95 | | Glendale | Smithville | 12/2/2017 | |
| 42 | 94 | | Bishop LeBlond | St. James | 3/1/1975 | |
| 42 | 94 | | Scott County Central | Slater | 3/1/1980 | |
| 42 | 94 | | Glendale | Hickman | 2/9/2026 | |
| 45 | 93 | | Glendale | Lebanon | 1/16/2018 | |