| Rank | Student | School | Years | | G | AST |
| 1 | Ryan Robertson | St. Charles West | 1992-1995 | | 118 | 1170 |
| 2 | Brad Parrack | St. Charles West | 1990-1993 | | 118 | 1065 |
| 3 | Anthony Beane | Bernie | 1987-1990 | | 116 | 824 |
| 4 | Terry Tauai | Verona | 1994-1997 | | 108 | 815 |
| 5 | Jake Welch | Bernie | 2006-2010 | | 112 | 772 |
| 6 | Ricky Forge | St. Mary's (Independence) | 1982-1985 | | 92 | 756 |
| 7 | Ron Ressel | Notre Dame (Cape Girardeau) | 1984-1987 | | 95 | 743 |
| 8 | Jared Johnson | Whitfield | 1991-1994 | | 97 | 724 |
| 9 | Andy Smelser | Risco | 1973-1974 | | 54 | 702 |
| 10 | TIm Lowery | Scott City | 1995-1998 | | 91 | 670 |
| 11 | Andrew Beckemeier | Winfield | 2002-2005 | | 98 | 642 |
| 12 | Rob Dowis | Sheridan High School | 1969-1971 | | 83 | 638 |