| Rank | Student | Grade | School | Year | | FGM | FGA | Total |
| 1 | Drew Dieckhoff | Sr | Concordia | 1995-1996 | | 221 | 288 | 76.7% |
| 2 | Kevin Irving | Jr | Liberty (Mountain View) | 1987-1988 | | 310 | 416 | 74.5% |
| 3 | Mike Martin | Sr | St. Francis Borgia | 1980-1981 | | 285 | 384 | 74.2% |
| 4 | Dexter Frisbie | Sr | Iberia | 2015-2016 | | 280 | 378 | 74.1% |
| 5 | Scott Brakebill | Sr | Bolivar | 1997-1998 | | 246 | 336 | 73.2% |
| 6 | Fred Johnson | Sr | Wellsville-Middletown | 1985-1986 | | 449 | 616 | 72.9% |
| 7 | Aaron Brinker | Sr | Pacific | 2003-2004 | | 197 | 272 | 72.4% |
| 8 | Ben Roberts | Sr | Forsyth | 1999-2000 | | 165 | 228 | 72.4% |
| 9 | Tyler Hansbrough | Sr | Poplar Bluff | 2002-2003 | | 280 | 387 | 72.4% |
| 10 | Dan Dohogne | Sr | Notre Dame (Cape Girardeau) | 1986-1987 | | 274 | 381 | 71.9% |
| 11 | Ron Williams | Sr | Berkeley High School | 1979-1980 | | 159 | 222 | 71.6% |
| 12 | Jacob Lafferty | So | Sparta | 2021-2022 | | 217 | 334 | 65.0% |
| 13 | Skylar John Thompson | So | Fort Osage | 2013-2014 | | 147 | 233 | 63.1% |
| 14 | Bradyn John Porter | Sr | Skyline | 2020-2021 | | 198 | 319 | 62.1% |
| 15 | Brian Starr | Sr | Fort Osage | 2013-2014 | | 131 | 212 | 61.8% |