| Rank | Student | Grade | School | Year | | G | Pts |
| 1 | Lionel Smith | Sr | Madison | 1952-1953 | | 35 | 1284 |
| 2 | John Brown | Sr | Dixon | 1968-1969 | | 36 | 1133 |
| 3 | Joe Scott | Sr | Gainesville | 1956-1957 | | 35 | 1104 |
| 4 | Bill Roundtree | Sr | Wellsville-Middletown | 1981-1982 | | 29 | 1096 |
| 5 | Brian Blackburn | Sr | Puxico | 1989-1990 | | 30 | 1076 |
| 6 | Aminu Mohammed | So | Greenwood | 2018-2019 | | 31 | 1059 |
| 7 | Fred Johnson | Sr | Wellsville-Middletown High School | 1985-1986 | | 32 | 1051 |
| 8 | Bill Bradley | Sr | Crystal City | 1960-1961 | | 29 | 1046 |
| 9 | Aminu Mohammed | Jr | Greenwood | 2019-2020 | | 30 | 1043 |
| 10 | Brad Parrack | Sr | Macks Creek | 1992-1993 | | 30 | 1042 |
| 11 | Michael Howard | Sr | Plattsburg | 2023-2024 | | 30 | 1032 |
| 12 | Paul Werle | Sr | Orrick | 1987-1988 | | 25 | 1023 |
| 13 | Dick Tharp | Sr | Meadville | 1980-1981 | | 28 | 1003 |
| 14 | Tony Osburn | Sr | Mound City | 2021-2022 | | 28 | 994 |
| 15 | Ryder Joseph Williams | Sr | Versailles | 2023-2024 | | 28 | 918 |
| 16 | Carter Trumbore | Sr | Butler | 2023-2024 | | 28 | 869 |
| 17 | Carter Trumbore | Jr | Butler | 2022-2023 | | 28 | 814 |
| 18 | Jordan Fuemmeler | Sr | Glasgow | 2023-2024 | | 27 | 791 |
| 19 | Brock Morey | Sr | Ellington | 2024-2025 | | 22 | 738 |
| 20 | Carter Trumbore | So | Butler | 2021-2022 | | 27 | 554 |
| 21 | Carson Andrew Erwin | Jr | Brashear | 2022-2023 | | 29 | 549 |