| Rank | STL | Student | School | Opponent | Date | |
| 1 | 18 | Ken Robinson | Brentwood | Management Center | 12/1/1989 | |
| 2 | 16 | Laydon Fields | Green City | Gilman City | 1/4/2019 | |
| 3 | 14 | Robert Mings | Plato | Cabool | 1/6/1997 | |
| 3 | 14 | Eli Hequembourg | Twin Rivers | Cedar Ridge, AR | 11/29/2025 | |
| 5 | 13 | Alvin Miller | Kirkwood | Hazelwood East | 12/18/1981 | |
| 5 | 13 | Basil Robinson | Memorial High School (Joplin) | East Newton | 1/2/1982 | |
| 5 | 13 | Basil Robinson | Memorial High School (Joplin) | Hillcrest | 1/8/1982 | |
| 5 | 13 | Shane Meyers | Marion County | Wyaconda | 2/17/1997 | |
| 5 | 13 | Josh Hume | Seymour | Forsyth | 1/9/1998 | |
| 5 | 13 | Corey Baker | Hale | Stet | 2/22/2007 | |
| 5 | 13 | Tim Gorman | Schuyler County | Marceline | 12/5/2008 | |
| 12 | 12 | Jeff Lorenz | Pilot Grove | Bunceton | 1/21/1990 | |
| 12 | 12 | Demond McClelland | Riverview Gardens | Pattonville | 2/25/1992 | |
| 12 | 12 | Josh Hume | Seymour | Conway | 12/12/1996 | |
| 12 | 12 | Logan Ray | Dixon | Laquey | 2/21/2006 | |
| 12 | 12 | Laydon Fields | Green City | Madison | 11/29/2021 | |
| 12 | 12 | Mark Panagos | Scott City | Delta | 1/11/2022 | |
| 12 | 12 | Brock Morey | Ellington | Bismarck | 2/7/2025 | |
| 19 | 11 | Jared Cooley | Penney | Lathrop | 12/19/2025 | |
| 20 | 10 | Zach Cotner | Scott City | | 1/10/2012 | vs. Delta |
| 20 | 10 | Fernando Gonzalez | Wheaton | Exeter | 2/13/2024 | |
| 22 | 9 | Zach Cotner | Scott City | | 2/1/2011 | |
| 22 | 9 | Carter Trumbore | Butler | Warsaw | 1/4/2022 | |
| 22 | 9 | Jadis Jones | Central (New Madrid County) | Summit Christian Academy | 1/1/2024 | |
| 22 | 9 | Lawson M Gurley | Senath-Hornersville | Holcomb | 12/9/2025 | |
| 22 | 9 | Jamarious White | Senath-Hornersville | Southland | 12/4/2025 | |
| 27 | 8 | Leonard Johnson | Kirkwood | Vashon | 3/1/1979 | |
| 27 | 8 | Pat Walter | Jefferson (Conception) | Springfield Catholic | 3/1/1984 | |
| 27 | 8 | Anthony Rodebush | Van Buren | New Bloomfield | 3/1/1992 | |
| 27 | 8 | Austin Segers | Bell City | La Plata | 3/1/2007 | |
| 27 | 8 | Hunter Gilkey | Walnut Grove | Advance | 3/1/2017 | |
| 27 | 8 | Josh Ruble | St. Pius X (Festus) | Valley Park | 12/5/2019 | |
| 27 | 8 | Josh Ruble | St. Pius X (Festus) | Principia | 2/18/2020 | |
| 27 | 8 | Patrick Farmer Jr. | Charleston | Duchesne | 1/1/2022 | |