| Rank | Total | Student | School | Opponent | Date | |
| 1 | 93 | J. D. Boyer | Winona | Fremont | 2/8/1955 | |
| 2 | 92 | George "Luke" Wilson | Elsberry | O'Fallon | 2/24/1953 | |
| 3 | 87 | Brooks Chambers | Jamestown | Olean | 11/1/1938 | |
| 4 | 79 | Leroy Boyer | New Bloomfield | Chamois | 1/1/1955 | |
| 5 | 71 | Lionel Smith | Madison | Renick | 2/25/1953 | |
| 5 | 71 | Scott Wolfe | Kemper High School | Higbee | 2/16/1973 | |
| 7 | 67 | Charles R. Miller | Assumption High School (O'Fallon) | Naylor | 1/28/1953 | |
| 7 | 67 | Larry Danks | Grundy High School | Ravanna | 1/19/1973 | |
| 7 | 67 | Cortez Dobbins | Malden | Senath-Hornersville | 1/13/2015 | |
| 10 | 66 | Percy Wells | Central High School (St. Louis) | Soldan | 1/20/1971 | |
| 10 | 66 | Matthew Horn | Hermitage | | 2/9/2019 | |
| 12 | 65 | Billy Earl Hogue | Southwest City High School | White Rock | 2/15/1950 | |
| 12 | 65 | Steve Griesinger | Albany | Martinsville | 2/18/1985 | At Stanberry |
| 12 | 65 | Paul Werle | Orrick | Stet | 1/29/1988 | |
| 12 | 65 | Jerome Jones | Miller Career Academy | Gateway | 1/9/2009 | |
| 12 | 65 | Daniel Berghtoldt | Valle Catholic | Zalma | 12/29/2014 | |
| 12 | 65 | Dylan Coleman | Potosi | Union | 2/27/2015 | |
| 18 | 61 | Jim Krebs | Webster Groves | Marshall | 3/1/1953 | |
| 18 | 61 | Jackson Lloyd | Winona | | 11/14/1969 | |
| 20 | 59 | Jon Beck | Scott City | | 12/9/1997 | |
| 21 | 54 | Greg Wakefield | Winona | | 1/17/1995 | |
| 22 | 53 | Roscoe Robinson | Westran | Salisbury | 2/24/2009 | |
| 23 | 52 | Ted Landers | Risco | | 2/18/1977 | |
| 24 | 51 | Wilson Murray | Licking | Houston | 11/23/2020 | |
| 25 | 50 | Jason Buckner | Licking | Mansfield | 2/24/1992 | |
| 26 | 49 | Eric Eikelman | Blair Oaks | Eldon | 1/20/1989 | |
| 26 | 49 | Lane Duncan | Licking | Houston | 2/24/2015 | |
| 28 | 48 | Chris Smith | Nevada | Mexico | 3/1/1991 | |
| 28 | 48 | Cory Via | Harrisburg | Laquey | 3/1/2009 | |
| 30 | 47 | Lawrence Rucker | Westran | Northeast (Cairo) | 2/10/1959 | |
| 30 | 47 | Kent Russell | Nixa | Lilbourn | 3/1/1978 | |
| 30 | 47 | Anthony Timmons | Scott County Central | Clopton | 3/1/1983 | |
| 33 | 46 | Dennis Droege | Concordia | | 2/21/1966 | |
| 33 | 46 | James Fleener | Polo | Polo | 1/20/2017 | |
| 33 | 46 | Devin Fields | Green City | | 1/19/2018 | vs. Novinger |
| 33 | 46 | Matthew Gatewood | Concordia | | 1/31/2019 | |
| 37 | 45 | Brandon Klaus | DeSoto | Jefferson City | 3/1/1993 | |
| 37 | 45 | Tim Scheer | New Haven | bishop Hogan High | 3/1/1997 | |
| 37 | 45 | C.E. Talton | Monroe City | | 2/3/2018 | |
| 40 | 44 | Larry Wilgus | La Plata | Southwest (Mooresville) | 3/1/1959 | |
| 40 | 44 | Greg Wakefield | Winona | | 12/9/1994 | |
| 42 | 43 | Jordan Barnett | Christian Brothers College | Hickman | 3/1/2000 | |
| 42 | 43 | Eric Helms | Seymour | | 12/6/2018 | |
| 42 | 43 | Hunter Lane | Macks Creek | Walnut Grove | 1/10/2020 | |
| 45 | 42 | Bill George | Waynesville | Morehouse | 3/1/1953 | |
| 45 | 42 | Ken Castagna | Westran | Salisbury | 12/7/1965 | |
| 45 | 42 | John Pfannkuch | Concordia | | 1/24/1978 | vs. K.C. West |
| 45 | 42 | Lamont Frazier | Charleston | McCluer South-Berkeley | 3/1/1989 | |
| 45 | 42 | Levi Cook | Crane | Bernie | 3/1/2011 | |
| 45 | 42 | Hunter Lane | Macks Creek | | 12/28/2018 | vs. Montrose |
| 51 | 41 | Dennis Droege | Concordia | | 1/29/1966 | |
| 51 | 41 | Tony Ford | Westran | North Callaway | 2/10/1987 | |
| 51 | 41 | Greg Wakefield | Winona | | 1/21/1995 | |
| 51 | 41 | Colton Walter | Macks Creek | Fair Play | 2/13/2020 | |
| 51 | 41 | Shaun Isom | Metro | McKinley Classical Leadership | 1/24/2020 | |
| 56 | 40 | Fred Inman | Concordia | | 12/19/1967 | vs. Knob Noster |
| 56 | 40 | Greg Wakefield | Winona | | 12/20/1994 | |