| Rank | Student | School | Opponent | Date | | H | Pts |
| 1 | Ted Landers | Risco | | 2/18/1977 | | 32 | 52 |
| 2 | Martez Harrison | University Academy Charter | Harrisonville | 12/2/2011 | | | 44 |
| 2 | Matthew Horn | Hermitage | | 2/9/2019 | | 2 | 44 |
| 4 | John Brown | Dixon | Vienna | 2/14/1969 | | 2 | 43 |
| 4 | Josh Ennis | Jamestown | Higbee | 1/29/2005 | At Otterville | 2 | 43 |
| 6 | Tony Osburn | Mound City | Worth County | 2/24/2022 | | 1 | 41 |
| 7 | David Salmon | Sherwood | Adrian | 2/11/1972 | | 2 | 39 |
| 7 | Andrew Capps | Tina-Avalon | Northwestern (Mendon) | 3/5/2003 | At Meadville | 2 | 39 |
| 7 | Clayton Schieber | Jefferson (Conception) | ACE Academy | 1/26/2012 | | 2 | 39 |
| 7 | Alex Pritzel | Cole Camp | Skyline | 1/26/2016 | | 2 | 39 |
| 7 | Carter Trumbore | Butler | Versailles | 1/18/2024 | | 1 | 39 |
| 12 | Lanny May | Bunker | Lesterville | 1/10/2002 | | 1 | 38 |
| 12 | Grant Coomer | Delta | | 1/5/2018 | | 1 | 38 |
| 14 | Joe Cravens | Clearwater | Portageville | 2/21/1981 | | 2 | 37 |
| 14 | Terrence Below | Delta | Chaffee | 2/14/2006 | | 2 | 37 |
| 14 | Tyrin Williams | Riverview Gardens | Northwest Academy | 1/11/2012 | | 2 | 37 |
| 14 | Maguire Scheer | Southern Boone | Linn | 1/31/2017 | | 1 | 37 |
| 14 | Tony Osburn | Mound City | Tarkio | 12/1/2021 | | 1 | 37 |
| 19 | Paul Werle | Orrick | Stet | 1/29/1988 | | 1 | 36 |
| 19 | Mike Lawson | Pattonsburg | North Daviess | 12/8/1989 | | 1 | 36 |
| 19 | Andrew Kueher | Sweet Springs | Windsor | 1/27/2007 | | 2 | 36 |
| 19 | Dietrick Sooter | Pierce City | Greenfield | 2/3/2009 | | 1 | 36 |
| 23 | Drew McMillin | Republic | Camdenton | 1/28/2021 | | 2 | 34 |
| 24 | Greg Wakefield | Winona | | 2/8/1993 | | 31 | 33 |
| 24 | Matthew Gatewood | Concordia | | 1/31/2019 | | 1 | 33 |
| 24 | Blake Fowler | Campbell | Bernie | 12/6/2019 | | 2 | 33 |
| 24 | Damario Moss | Lexington | Lexington | 12/1/2022 | | 2 | 33 |
| 28 | Jacob Smith | Winona | | 1/26/2013 | | 2 | 32 |
| 29 | Dave Brent | Sumner | Hickman | 3/1/1969 | | 1 | 31 |
| 29 | Greg Wakefield | Winona | | 2/8/1993 | | 2 | 31 |
| 31 | Greg Wakefield | Winona | | 1/17/1995 | | 2 | 30 |
| 31 | Gaige Pitts | Thayer | Houston | 2/2/2021 | | 1 | 30 |
| 31 | Tony Osburn | Mound City | Rock Port | 1/5/2021 | | 1 | 30 |
| 31 | Keegan Gracey | Clearwater | Zalma | 11/18/2022 | | 1 | 30 |
| 31 | Carter Trumbore | Butler | Adrian | 1/5/2023 | | 2 | 30 |
| 31 | Charles Robbins | Clearwater | Twin Rivers | 2/8/2024 | | 2 | 30 |
| 37 | Casey Teson | St. Charles | | 3/21/2015 | | 2 | 29 |
| 37 | Aminu Mohammed | Greenwood | Fordland | 12/13/2018 | | 1 | 29 |
| 37 | Drenin Dinkins | South Iron | South Iron | 3/12/2022 | | 1 | 29 |
| 40 | Andy St. Clair | Brookfield | Forsyth | 3/1/1993 | | 2 | 28 |
| 40 | Aminu Mohammed | Greenwood | Purdy | 11/26/2018 | | 1 | 28 |
| 40 | Aminu Mohammed | Greenwood | Fordland | 1/25/2019 | | 2 | 28 |
| 43 | Kent Russell | Nixa | Lilbourn | 3/1/1978 | | 2 | 27 |
| 43 | Chris Smith | Nevada | Festus | 3/1/1991 | | 2 | 27 |
| 43 | Chris Smith | Nevada | Mexico | 3/1/1991 | | 1 | 27 |
| 43 | Brandon Klaus | DeSoto | Jefferson City | 3/1/1993 | | 2 | 27 |
| 43 | Greg Wakefield | Winona | | 1/21/1995 | | 2 | 27 |
| 43 | JaRon Rush | Pembroke Hill | Fatima | 3/1/1996 | | 2 | 27 |
| 43 | Dwayne Polk | Vashon | Kearney | 3/1/2004 | | 2 | 27 |
| 43 | Jayson Christopher Tatum | Chaminade | Kickapoo | 3/1/2016 | | 1 | 27 |
| 43 | Aminu Mohammed | Greenwood | Kickapoo | 12/30/2019 | | 2 | 27 |
| 43 | Brandon Jochimsen | Brashear | Marion County | 1/9/2020 | | 1 | 27 |
| 43 | Drew McMillin | Republic | Camdenton | 1/28/2021 | | 1 | 27 |
| 43 | Blake Fowler | Campbell | South Pemiscot | 2/23/2021 | | 2 | 27 |
| 43 | Cole Nichols | Dexter | Richland (Essex) | 12/12/2022 | | 1 | 27 |
| 43 | Carson Erwin | Brashear | Madison | 2/3/2023 | | 1 | 27 |
| 43 | Carter Trumbore | Butler | Holden | 1/12/2023 | | 2 | 27 |
| 58 | Marty Hardin | Hallsville | Penney | 3/1/1981 | | 1 | 26 |
| 58 | Greg Caudle | New Bloomfield | Wellington-Napoleon | 3/1/1991 | | 1 | 26 |
| 58 | Carter Trumbore | Butler | El Dorado Springs | 2/6/2024 | | 2 | 26 |
| 61 | Carter Trumbore | Butler | Hume | 2/5/2024 | | 1 | 25 |