| Rank | Student | Grade | School | Year | | TD | M | Total |
| 1 | Karson Hill | Sr | Trenton | 2011-2012 | | 559 | 46 | 12.15 |
| 2 | T.J. Hill | Sr | Farmington | 1997-1998 | | 387 | 43 | 9.00 |
| 3 | Curtis Bledsoe | Sr | Hazelwood East | 1999-2000 | | 329 | 38 | 8.66 |
| 4 | Rodney Pettit | Sr | Belton | 2002-2003 | | 311 | 42 | 7.40 |
| 5 | Wyatt Pickering | Sr | Chillicothe | 1998-1999 | | 294 | 41 | 7.17 |
| 6 | Jeramiah Warren Smith | Sr | Summit Christian Academy | 2022-2023 | | 366 | 52 | 7.04 |
| 7 | Jerome Frazier | Sr | Lincoln College Prep | 1993-1994 | | 295 | 42 | 7.02 |
| 8 | Brian Roskin | Sr | MICDS | 1999-2000 | | 301 | 43 | 7.00 |
| 9 | Gary Lindsay | Jr | Brookfield | 2009-2010 | | 346 | 51 | 6.78 |
| 10 | Jon Ott | Sr | DeSmet | 2000-2001 | | 284 | 42 | 6.76 |
| 11 | Kyle Newham | | Richmond | 1996-1997 | | 262 | 40 | 6.55 |
| 12 | James Anding | Sr | Pacific | 2018-2019 | | 334 | 51 | 6.55 |
| 13 | Kyler James Rea | Sr | Neosho | 2015-2016 | | 364 | 58 | 6.28 |
| 14 | Cevion Jordan Severado | Jr | Christian Brothers College | 2016-2017 | | 247 | 49 | 5.04 |
| 15 | Jake Hunter | Jr | Harrisonville | 2006-2007 | | 235 | 49 | 4.80 |
| 16 | Bryce Newham | Fr | Boonville | 2024-2025 | | 206 | 51 | 4.04 |
| 17 | Leo Theodore Buchheit | Sr | North Point | 2024-2025 | | 169 | 48 | 3.52 |
| 18 | Kailey Michelle Benson | Sr | Francis Howell Central | 2024-2025 | | 138 | 48 | 2.88 |
| 19 | | Jr | Lebanon | 2018-2019 | | 153 | 54 | 2.83 |
| 19 | Trevor Christian | Jr | Lebanon | 2018-2019 | | 153 | 54 | 2.83 |
| 21 | Kailey Michelle Benson | Jr | Francis Howell Central | 2023-2024 | | 113 | 45 | 2.51 |
| 22 | Arianna Augustyniak | Jr | St. Charles West | 2025-2026 | | 100 | 49 | 2.04 |
| 23 | Arianna Augustyniak | So | St. Charles West | 2024-2025 | | 81 | 46 | 1.76 |
| 24 | Antionna Cunningham | Fr | Lebanon | 2018-2019 | | 62 | 36 | 1.72 |
| 25 | Lexington Johnson | Sr | St. Charles West | 2025-2026 | | 97 | 60 | 1.62 |
| 26 | Payton Weese | Jr | Marceline | 2022-2023 | | 70 | 47 | 1.49 |
| 27 | Zoey Joanne Haney | So | Troy Buchanan | 2022-2023 | | 53 | 36 | 1.47 |
| 28 | Jaycee Foeller | So | DeSoto | 2018-2019 | | 51 | 35 | 1.46 |
| 29 | Jaycee Foeller | Jr | DeSoto | 2019-2020 | | 66 | 46 | 1.43 |
| 30 | Jessa Joiner | Fr | Lebanon | 2021-2022 | | 64 | 46 | 1.39 |
| 31 | Bailey Joiner | Jr | Lebanon | 2021-2022 | | 52 | 39 | 1.33 |
| 31 | Sarah Grace Bergtholdt | Jr | Troy Buchanan | 2022-2023 | | 32 | 24 | 1.33 |
| 33 | Kaylyn Rogers | Sr | Lebanon | 2021-2022 | | 61 | 46 | 1.33 |
| 34 | Jaycee Foeller | Sr | DeSoto | 2020-2021 | | 51 | 39 | 1.31 |
| 35 | Emily Young | So | Lebanon | 2018-2019 | | 40 | 32 | 1.25 |
| 35 | Darby Neely | Fr | Lebanon | 2018-2019 | | 35 | 28 | 1.25 |
| 37 | Antionna Cunningham | So | Lebanon | 2019-2020 | | 58 | 47 | 1.23 |
| 38 | Ashlynn Leochner | Jr | Lebanon | 2018-2019 | | 41 | 37 | 1.11 |
| 39 | Bailey Joiner | So | Lebanon | 2020-2021 | | 51 | 49 | 1.04 |
| 40 | Halea Bartel | So | Lebanon | 2021-2022 | | 42 | 41 | 1.02 |
| 41 | Ashlynn Leochner | Sr | Lebanon | 2019-2020 | | 49 | 48 | 1.02 |
| 42 | Bailey Joiner | Fr | Lebanon | 2019-2020 | | 48 | 48 | 1.00 |
| 42 | Quincey Glendenning | Sr | Lebanon | 2021-2022 | | 44 | 44 | 1.00 |
| 44 | Jasmine Alley | Jr | Lebanon | 2021-2022 | | 43 | 46 | 0.93 |
| 45 | Talora Frisbee | Fr | Lebanon | 2018-2019 | | 37 | 40 | 0.93 |
| 46 | Quincey Glendenning | Jr | Lebanon | 2020-2021 | | 43 | 47 | 0.91 |
| 47 | Mariyah Brumley | So | Lebanon | 2021-2022 | | 41 | 45 | 0.91 |
| 48 | Taylor Johnson | So | Lebanon | 2020-2021 | | 40 | 46 | 0.87 |