| Rank | Student | School | Years | | AST | G | Total |
| 1 | Blane Brown | Kearney | 2004-2007 | | 98 | 107 | 0.92 |
| 2 | Seth Wiebusch | Harrisonville | 2014-2017 | | 92 | 101 | 0.91 |
| 3 | Joshua B Udinyiwe | Boonville | 2013-2016 | | 74 | 86 | 0.86 |
| 4 | Nick Golden | Grandview | 1997-2000 | | 69 | 85 | 0.81 |
| 5 | Alec S Adair | Boonville | 2013-2016 | | 68 | 86 | 0.79 |
| 6 | Greg Koeller | St. Thomas Aquinas-Mercy | 1980-1982 | | 64 | 84 | 0.76 |
| 7 | Caleb Grabill | Harrisonville | 2007-2010 | | 68 | 97 | 0.70 |
| 8 | Cole Harkrader | Harrisonville | 2012-2015 | | 70 | 104 | 0.67 |
| 9 | Colton Harden | Marshfield | 2007-2010 | | 62 | 93 | 0.67 |
| 10 | Cory Allensworth | Hannibal | 2014-2017 | | 65 | 101 | 0.64 |
| 11 | Cody Blentlinger | Harrisonville | 2008-2011 | | 62 | 97 | 0.64 |
| 12 | Brandon Moore | Rolla | 2002-2004 | | 50 | 80 | 0.63 |
| 13 | Hunter Short | Rolla | 2010-2013 | | 68 | 112 | 0.61 |
| 14 | John McQueary | Greenwood | 1994-1997 | | 53 | 92 | 0.58 |
| 15 | John Johnson | Christian Brothers College | 1981-1984 | | 57 | 100 | 0.57 |
| 16 | Mark Filla | St. Thomas Aquinas-Mercy | 1991-1994 | | 54 | 96 | 0.56 |
| 17 | Jonathan Najera | Marshall | 2007-2010 | | 54 | 100 | 0.54 |
| 18 | Charles Allen | Pembroke Hill | 2007-2010 | | 54 | 106 | 0.51 |