| Rank | Student | School | Years | | AST | G | AVG |
| 1 | Diego Hernan Perez | Oak Grove | 2021-2024 | | 80 | 70 | 1.14 |
| 1 | Diego Hernan Perez | Oak Grove | 2021-2024 | | 80 | 70 | 1.14 |
| 3 | Ethan David Bromaghim | Orchard Farm | 2017-2020 | | 79 | 82 | 0.96 |
| 4 | Blane Brown | Kearney | 2004-2007 | | 98 | 107 | 0.92 |
| 5 | Seth Wiebusch | Harrisonville | 2014-2017 | | 92 | 101 | 0.91 |
| 6 | Joshua B Udinyiwe | Boonville | 2013-2016 | | 74 | 86 | 0.86 |
| 7 | Nick Golden | Grandview | 1997-2000 | | 69 | 85 | 0.81 |
| 8 | Alec S Adair | Boonville | 2013-2016 | | 68 | 86 | 0.79 |
| 9 | Owen Bailey | Pleasant Hill | 2017-2020 | | 65 | 83 | 0.78 |
| 10 | Greg Koeller | St. Thomas Aquinas-Mercy | 1980-1982 | | 64 | 84 | 0.76 |
| 11 | Bodie Rollins | Hannibal | 2021-2024 | | 70 | 97 | 0.72 |
| 12 | Gauge Fleschute | Laquey | 2019-2022 | | 70 | 98 | 0.71 |
| 12 | Gauge Fleschute | Laquey | 2019-2022 | | 70 | 98 | 0.71 |
| 14 | Caleb Grabill | Harrisonville | 2007-2010 | | 68 | 97 | 0.70 |
| 15 | Cole Harkrader | Harrisonville | 2012-2015 | | 70 | 104 | 0.67 |
| 16 | Colton Harden | Marshfield | 2007-2010 | | 62 | 93 | 0.67 |
| 17 | Cory Allensworth | Hannibal | 2014-2017 | | 65 | 101 | 0.64 |
| 18 | Cody Blentlinger | Harrisonville | 2008-2011 | | 62 | 97 | 0.64 |
| 19 | Brandon Moore | Rolla | 2002-2004 | | 50 | 80 | 0.63 |
| 20 | Hunter Short | Rolla | 2010-2013 | | 68 | 112 | 0.61 |
| 21 | Ethan Larson | Laquey | 2020-2023 | | 56 | 93 | 0.60 |
| 21 | Ethan Larson | Laquey | 2020-2023 | | 56 | 93 | 0.60 |
| 23 | Tristen Carriger | Laquey | 2020-2023 | | 45 | 75 | 0.60 |
| 24 | John McQueary | Greenwood | 1994-1997 | | 53 | 92 | 0.58 |
| 25 | John Johnson | Christian Brothers College | 1981-1984 | | 57 | 100 | 0.57 |
| 26 | Mark Filla | St. Thomas Aquinas-Mercy | 1991-1994 | | 54 | 96 | 0.56 |
| 27 | Jonathan Najera | Marshall | 2007-2010 | | 54 | 100 | 0.54 |
| 28 | Charles Allen | Pembroke Hill | 2007-2010 | | 54 | 106 | 0.51 |
| 29 | Rylen Ballard | Logan-Rogersville | 2018-2021 | | 46 | 94 | 0.49 |
| 29 | | Laquey | 2022-2025 | | 46 | 94 | 0.49 |
| 29 | Rhyder Andrew Martin | Laquey | 2022-2025 | | 46 | 94 | 0.49 |
| 32 | Sage Ballard | Logan-Rogersville | 2018-2021 | | 40 | 94 | 0.43 |