| Rank | Time | Student | Grade | School | Year | |
| 1 | 10:19.15 | Taylor Werner | | Ste. Genevieve | 2014 | Class 3 |
| 2 | 10:24.12 | Emily P. Sisson | | Parkway Central | 2009 | Class 4 |
| 3 | 10:25.95 | Megan Thompson | | Hazelwood Central | 1990 | Class 4 |
| 4 | 10:27.62 | Colleen Quigley | | Nerinx Hall | 2011 | Class 4 |
| 5 | 10:29.08 | Jamie Elizabeth Kempfer | | Festus | 2014 | Class 3 |
| 6 | 10:38.04 | Taylor Werner | | Ste. Genevieve | 2013 | Class 3 |
| 7 | 10:38.38 | Anna Marie West | | Lafayette (Wildwood) | 2015 | Class 5 |
| 8 | 10:38.71 | Ann Elizabeth Campbell | | St. Teresa's Academy | 2015 | Class 5 |
| 9 | 10:40.34 | Sarah Jane Nicholson | | Lafayette (Wildwood) | 2016 | Class 5 |
| 10 | 10:53.38 | Claire Workman | | New Covenant Academy | 2016 | Class 1 |
| 11 | 10:56.82 | Amber Warren | | Lutheran St. Charles | 2005 | Class 2 |
| 12 | 11:01.51 | Heather Burroughs | | Pembroke Hill | 1994 | Class 2 |
| 13 | 11:02.44 | Terry Phillips | | St. Mary's (Independence) | 2007 | Class 2 |
| 14 | 11:25.70 | Alexys Barton | | Liberal | 2016 | Class 1 |
| 15 | 11:30.38 | Claire McCune | | New Covenant Academy | 2016 | Class 1 |