| Rank | Time | Student | Grade | School | Year | |
| 1 | 4:40.15 | Hannah Long | | Eureka | 2015 | Class 5 |
| 2 | 4:44.26 | Taylor Werner | | Ste. Genevieve | 2014 | Class 3 |
| 3 | 4:45.61 | Anna Marie West | | Lafayette (Wildwood) | 2016 | Class 5 |
| 4 | 4:46.21 | Hannah Long | | Eureka | 2014 | Class 4 |
| 5 | 4:47.53 | Megan Thompson | | Hazelwood Central | 1989 | Class 4 |
| 6 | 4:47.56 | Andrea Fischer | | Hannibal | 1981 | Class 4 |
| 7 | 4:49.27 | Jamie Elizabeth Kempfer | | Festus | 2014 | Class 3 |
| 8 | 4:51.47 | Sarah Jane Nicholson | | Lafayette (Wildwood) | 2016 | Class 5 |
| 9 | 4:51.70 | Alyssa Nichole Allison | | Festus | 2008 | Class 3 |
| 10 | 4:54.98 | Elyse Wilmes | | Father Tolton Regional Catholic | 2022 | Class 2 |
| 11 | 5:00.93 | Courtney Rogers | | Lutheran (St. Charles) | 2014 | Class 2 |
| 12 | 5:01.09 | Claire Workman | | New Covenant Academy | 2016 | Class 1 |
| 13 | 5:01.93 | Amber Warren | | Lutheran (St. Charles) | 2005 | Class 2 |
| 14 | 5:03.00 | Gwen Williams | | Principia | 1992 | Class 2 |
| 15 | 5:08.74 | Alexys Barton | | Liberal | 2016 | Class 1 |
| 16 | 5:11.14 | Darla Curp | | Polo | 1981 | |