| Rank | Time | Student | Grade | School | Year | |
| 1 | 10.42 | Maurice Mitchell | | Raytown South | 2006 | Class 4 |
| 1 | 10.42 | Maurice Mitchell | | Raytown South | 2007 | Class 4 |
| 3 | 10.44 | Jon Vaughn | | McCluer North | 1987 | Class 4A |
| 3 | 10.44 | Jon Vaughn | | McCluer North | 1988 | Class 4 |
| 5 | 10.47 | James Scott | | Southeast | 1987 | |
| 5 | 10.47 | James Scott | | Southeast | 1987 | Class 4 |
| 7 | 10.52 | Paul Chaney | | St. Louis University | 2005 | |
| 7 | 10.52 | Paul Chaney | | St. Louis University | 2006 | |
| 9 | 10.59 | Micah Beaver | | Raymore-Peculiar | 2016 | Class 5 |
| 10 | 10.60 | Jon Redmond | | Liberty North | 2016 | Class 5 |
| 11 | 10.65 | Jaron J Alexander | | Grandview | 2012 | Class 3 |
| 12 | 10.66 | Herbert Johnson | | Fulton | 1981 | Class 3 |
| 12 | 10.66 | Anthony Lewis | | Charleston | 1985 | Class 3 |
| 12 | 10.66 | Naron Rollins | | Platte County | 2012 | Class 3 |
| 15 | 10.74 | Eric Safford | | Maplewood-Richmond Hts. | 1992 | Class 2 |
| 15 | 10.74 | Kelvin Michael Wells | | Cleveland NJROTC | 2012 | Class 2 |
| 17 | 10.75 | Randal Drake | | Portageville | 1993 | Class 2 |
| 18 | 11.01 | Elijah Lee Mullock | | Worth County | 2011 | Class 1 |
| 19 | 11.03 | Robert Parker | | Missouri School for the Deaf | 1996 | Class 1 |
| 20 | 11.04 | Jeff Best | | Wellington-Napoleon | 1991 | Class 1 |