| Rank | Student | School | Opponent | Date | | FR | INT | Total |
| 1 | | Lincoln College Prep | Northeast (Kansas City) | 11/2/1985 | | 10 | 5 | 15 |
| 2 | | Mound City | St. Joseph Christian | 11/26/2010 | 8-Man | 4 | 5 | 9 |
| 3 | | Greenwood | Gallatin | 11/28/1981 | Class 1A | 4 | 4 | 8 |
| 3 | | Central (Cape Girardeau) | Poplar Bluff | 10/4/2019 | | 4 | 4 | 8 |
| 5 | | St. Vincent | East Buchanan | 11/23/2007 | Class 1 | 1 | 6 | 7 |
| 5 | | Drexel | St. Paul Lutheran (Concordia) | 10/22/2021 | | 1 | 6 | 7 |
| 5 | | Drexel | St. Paul Lutheran (Concordia) | 10/22/2021 | | 1 | 6 | 7 |
| 5 | | Sarcoxie | Clever | 8/31/2023 | | 4 | 3 | 7 |
| 9 | | Central (Park Hills) | Seneca | 12/1/2023 | | 2 | 2 | 4 |