| Rank | Student | School | Year | | G | SACK |
| 1 | | Lutheran South | 1981 | | 13 | 55 |
| 2 | | Parkway North | 2009 | | 12 | 49 |
| 2 | | South Shelby | 2010 | | 13 | 49 |
| 4 | | Wellington-Napoleon | 2009 | | 14 | 48 |
| 5 | | West Platte | 2003 | | 10 | 47 |
| 5 | | Harrisonville | 2006 | | 14 | 47 |
| 5 | | Parkway North | 2016 | | 14 | 47 |
| 8 | | Wright City | 2005 | | 11 | 46 |
| 9 | | Lexington | 1984 | | 13 | 45 |
| 10 | | Christian Brothers College | 1978 | | 10 | 41 |
| 11 | | Lebanon | 2010 | | 11 | 40 |