| Rank | Student | School | Year | | YDS | G | PerG |
| 1 | | Glendale | 2015 | | 6197 | 11 | 563.36 |
| 2 | | Union | 2007 | | 5998 | 11 | 545.27 |
| 3 | | Jackson | 2017 | | 5863 | 11 | 533.00 |
| 4 | | Pattonsburg | 2019 | | 6855 | 13 | 527.31 |
| 5 | | Ste. Genevieve | 2008 | | 6300 | 12 | 525.00 |
| 6 | | Central (Park Hills) | 2023 | | 7207 | 14 | 514.79 |
| 7 | | Montgomery County | 2003 | | 5629 | 11 | 511.73 |
| 8 | | Central (Park Hills) | 2021 | | 6132 | 12 | 511.00 |
| 9 | | Neosho | 2022 | | 5109 | 10 | 510.90 |
| 10 | | Union | 2006 | | 5455 | 11 | 495.91 |
| 11 | | Ft. Zumwalt West | 2010 | | 6369 | 13 | 489.92 |
| 12 | | Mid-Buchanan | 2020 | | 6788 | 14 | 484.86 |
| 13 | | Lamar | 2013 | | 7226 | 15 | 481.73 |
| 14 | | Ft. Zumwalt West | 2008 | | 5741 | 12 | 478.42 |
| 15 | | Valle Catholic | 2014 | | 7164 | 15 | 477.60 |
| 16 | | Westran | 2014 | | 7134 | 15 | 475.60 |
| 17 | | Father Tolton Regional Catholic | 2018 | | 5129 | 11 | 466.27 |
| 18 | | Ritenour | 2017 | | 5060 | 11 | 460.00 |
| 19 | | Valle Catholic | 2012 | | 6886 | 15 | 459.07 |
| 20 | | Odessa | 2019 | | 6882 | 15 | 458.80 |
| 21 | | Valle Catholic | 2015 | | 6879 | 15 | 458.60 |
| 22 | | Bolivar | 2005 | | 4568 | 10 | 456.80 |
| 23 | | Central (Park Hills) | 2017 | | 5886 | 13 | 452.77 |
| 24 | | Harrisonville | 2007 | | 6334 | 14 | 452.43 |
| 25 | | Central (Park Hills) | 2020 | | 4486 | 10 | 448.60 |
| 26 | | Joplin | 2019 | | 6210 | 14 | 443.57 |
| 26 | | Joplin | 2019 | 477.69 YPG | 6210 | 14 | 443.57 |
| 28 | | Fayette | 2021 | | 5760 | 13 | 443.08 |
| 29 | | Jackson | 2019 | | 6176 | 14 | 441.14 |
| 30 | | Salem | 2002 | | 6084 | 14 | 434.57 |
| 31 | | Maryville | 2012 | | 6516 | 15 | 434.40 |
| 32 | | Valle Catholic | 2009 | | 6440 | 15 | 429.33 |
| 33 | | Sweet Springs | 2019 | | 5109 | 12 | 425.75 |
| 34 | | Central (Park Hills) | 2015 | | 5458 | 13 | 419.85 |
| 35 | | Clinton | 1990 | | 5068 | 13 | 389.85 |
| 36 | | Monroe City | 2017 | | 5657 | 15 | 377.13 |
| 37 | | Maryville | 2012 | | 407 | 15 | 27.13 |