| Rank | Total | Student | School | Opponent | Date | |
| 1 | -52 | | Fair Grove | Skyline | 9/8/2023 | |
| 2 | -46 | | Lincoln College Prep | Northeast (Kansas City) | 11/2/1985 | |
| 3 | -44 | | St. Louis University | McCluer | 9/22/1967 | |
| 4 | -39 | | Windsor | Crest Ridge | 10/13/2023 | |
| 5 | -36 | | Rich Hill | Archie | 9/16/1994 | |
| 6 | -20 | | Hardin-Central | Kemper Military Academy | 9/25/1999 | |
| 7 | -11 | | Hardin-Central | Kemper Military Academy | 10/12/2001 | |
| 8 | -9 | | Central (Cape Girardeau) | Poplar Bluff | 10/8/2010 | |
| 9 | -3 | | North County Christian Sr | Potosi | 10/31/1997 | |
| 10 | -1 | | Pattonville | Normandy Collaborative | 10/25/1997 | |
| 11 | 2 | | Adrian | Osceola | 10/29/1999 | |