| Rank | YDS | Student | School | Opponent | Date | |
| 1 | 860 | | Sherwood | Maranatha Academy (KS) | 9/19/2008 | |
| 2 | 850 | | Washington | Holt | 10/9/2015 | |
| 3 | 825 | | St. James | Owensville | 10/27/2011 | |
| 4 | 824 | | Francis Howell North | Francis Howell Central | 9/26/2015 | |
| 5 | 783 | | Owensville | St. James | 10/27/2011 | |
| 6 | 780 | | Washington | Warrenton | 9/4/2015 | |
| 7 | 779 | | Lutheran North | Lutheran South | 9/26/2015 | |
| 8 | 774 | | Portageville | Scott City | 11/4/2022 | |
| 9 | 755 | | Neosho | Willard | 8/26/2022 | |
| 10 | 741 | | Union | St. Clair | 10/30/2008 | |
| 11 | 737 | | Central (Springfield) | Greenfield | 10/8/1927 | |
| 12 | 717 | | Neosho | Ozark | 10/7/2022 | |
| 13 | 713 | | Ste. Genevieve | Potosi | 10/21/2005 | |
| 14 | 711 | | Monroe City | Monroe City | 10/8/2021 | |
| 14 | 711 | | Monroe City | Macon | 10/8/2021 | |
| 16 | 706 | | Hermann | Union | 10/16/2015 | |
| 17 | 668 | | Chaffee | Veritas Christian HS | 10/11/2024 | |
| 18 | 661 | | Central (Park Hills) | Seneca | 12/1/2023 | |
| 19 | 635 | | DeSmet | Hazelwood Central | 11/25/2005 | |
| 20 | 630 | | Crest Ridge | Wellington-Napoleon | 9/1/2023 | |
| 21 | 629 | | Central (Park Hills) | Seneca | 12/1/2023 | Class 3 |
| 22 | 622 | | Warsaw | Buffalo | 10/21/2022 | |
| 23 | 620 | | Concordia | | 10/4/2019 | |
| 24 | 603 | | Neosho | Branson | 9/30/2022 | |
| 25 | 595 | | Valle Catholic | Westran | 11/28/2014 | |
| 26 | 594 | | Christian Brothers College | Rockhurst | 11/24/2018 | Class 6 |
| 27 | 593 | | Neosho | Carl Junction | 9/9/2022 | |
| 28 | 585 | | Priory | West Platte | 12/1/1973 | |
| 28 | 585 | | Concordia | Braymer | 10/8/2021 | |
| 30 | 578 | | Fort Osage | Chaminade | 11/28/2015 | |
| 31 | 577 | | Maryville | | 10/30/2008 | |
| 32 | 576 | | Lamar | Blair Oaks | 11/24/2012 | |
| 33 | 564 | | South Holt | St. Joseph Christian | 11/1/2004 | |
| 33 | 564 | | South Holt | St. Joseph Christian | 11/20/2024 | 8-Man |
| 35 | 549 | | Chaffee | Doniphan | 10/14/2022 | |
| 36 | 543 | | Penney | Valle Catholic | 11/23/2012 | |
| 37 | 538 | | MICDS | Webb City | 11/25/2011 | |
| 38 | 522 | | Schuyler County | | 9/27/2019 | |
| 39 | 514 | | North Andrew | Stanberry | 11/1/2015 | |
| 39 | 514 | | North Andrew | Stanberry | 11/27/2015 | 8-Man |
| 41 | 495 | | Mound City | North Andrew | 11/1/1999 | |
| 41 | 495 | | Mound City | North Andrew | 11/20/1999 | 8-Man |
| 43 | 485 | | Mound City | Southwest (Livingston County) | 11/30/2019 | 8-Man |
| 44 | 460 | | Mound City | North Andrew | 11/1/2003 | |
| 45 | 433 | | Miami | Worth County | 11/1/2001 | |