| Rank | Student | School | Years | | G | TD |
| 1 | Kellen Overstreet | Penney | 2011-2014 | | 56 | 135 |
| 2 | Jacob Coffey | Drexel | 2019-2022 | | 41 | 126 |
| 3 | Brad Hocker | Penney | 1988-1991 | | 45 | 125 |
| 4 | Caleb Schaffitzel | Fair Grove | 2006-2009 | | 47 | 119 |
| 5 | Dylan Jacob Hair | Blair Oaks | 2019-2022 | | 53 | 112 |
| 6 | Zane Jacoby | Westran | 2011-2014 | | 53 | 110 |
| 7 | Mack J Anderson | Southwest (Livingston County) | 2016-2019 | | 47 | 109 |
| 8 | Trevor Klein | East Buchanan | 2020-2023 | | 48 | 103 |
| 9 | Trevor Dixon | Penney | 2007-2010 | | 50 | 100 |
| 9 | Jacob Clay | Brentwood | 2012-2015 | | 45 | 100 |
| 11 | Lee Flood | Marionville | 2004-2006 | | 41 | 98 |
| 12 | Ted Sweets | Butler | 1960-1963 | | 40 | 90 |
| 12 | Max Mickey | Holden | 2010-2012 | | 36 | 90 |
| 14 | Javan Rae Noyes | Mid-Buchanan | 2017-2020 | | 52 | 81 |
| 15 | Dalton Krysa | Fort Osage | 2005-2008 | | 42 | 80 |
| 16 | Isaiah Davis | Joplin | 2017-2019 | | 37 | 76 |
| 16 | Patrick Carlton | Carthage | 2017-2020 | | 38 | 76 |
| 18 | Sawyer Morrow | Penney | 2017-2020 | | 49 | 74 |