| Rank | Student | Grade | School | Year | | G | SACK |
| 1 | Parker Chase Monnig | Jr | Ft. Zumwalt North | 2019 | | 12 | 24 |
| 2 | Tymon Coleman | Sr | Roosevelt | 2006 | | 10 | 23 |
| 3 | D.J. Hall | So | West Platte | 2003 | | 10 | 20.5 |
| 4 | Matt Plattner | Sr | Santa Fe | 1999 | | 14 | 20 |
| 4 | Frank Burrell | Jr | Hazelwood Central | 2003 | | 13 | 20 |
| 4 | Jason Patterson | Sr | Gateway Academy | 2004 | | 9 | 20 |
| 4 | Jamal Graham | So | Gateway Academy | 2005 | | 10 | 20 |
| 4 | Devin J. Lindsey | Sr | Maplewood-Richmond Hts. | 2008 | | 14 | 20 |
| 4 | Jon Stewart Reckamp | Sr | Wright City | 2008 | | 10 | 20 |
| 4 | Dane Jeffery Allen Wilckens | Sr | Concordia | 2025 | | 46 | 20 |
| 4 | Dane Jeffery Allen Wilckens | Sr | Concordia | 2025 | | 13 | 20 |
| 12 | Tony Buford | Sr | Lutheran North | 1981 | | 13 | 19 |
| 12 | Nate Storch | Jr | John Burroughs | 1991 | | 13 | 19 |
| 12 | Travis Maune | Sr | St. Francis Borgia | 1996 | | 13 | 19 |
| 12 | Nick Stemmler | Jr | Bishop DuBourg | 2004 | | 10 | 19 |
| 12 | Logan Lein | Jr | Wright City | 2005 | | 11 | 19 |
| 12 | Sheldon Richardson | Sr | Gateway Academy | 2008 | | 14 | 19 |