| Rank | Student | Grade | School | Year | | YDS | G | Total |
| 1 | Brody McMahon | Sr | Maryville | 2014 | | 4699 | 13 | 361.46 |
| 2 | Gunnar Martin | Sr | Polo | 2015 | | 3683 | 11 | 334.82 |
| 3 | Kellen Overstreet | Sr | Penney | 2014 | | 4259 | 14 | 304.21 |
| 4 | Caleb Schaffitzel | Jr | Fair Grove | 2008 | | 2759 | 10 | 275.90 |
| 5 | Brian Grimes | Sr | Trenton | 1990 | | 2943 | 11 | 267.55 |
| 6 | Brad Hocker | So | Archie | 1989 | | 3094 | 12 | 257.83 |
| 7 | Joshua McNelly | Sr | Norborne | 1996 | | 2565 | 10 | 256.50 |
| 8 | Montee Ball | Jr | Timberland | 2007 | | 3077 | 12 | 256.42 |
| 9 | Rayon Simmons | Sr | Christian Brothers College | 2007 | | 2519 | 10 | 251.90 |
| 10 | Trent Davis | Sr | Wright City | 2010 | | 2738 | 11 | 248.91 |
| 11 | Marquis Williams | Sr | St. Mary's (St. Louis) | 1992 | | 2458 | 10 | 245.80 |
| 12 | Mack J Anderson | Sr | Southwest (Livingston County) | 2019 | | 3146 | 13 | 242.00 |
| 13 | Max Mickey | Sr | Holden | 2012 | | 3382 | 14 | 241.57 |
| 14 | Lee Flood | Sr | Marionville | 2006 | | 3316 | 14 | 236.86 |
| 15 | Lee Flood | Jr | Marionville | 2005 | | 3272 | 14 | 233.71 |
| 16 | Robbie Allen | Sr | Butler | 1989 | | 3005 | 13 | 231.15 |
| 17 | Garren Vroman | Sr | Fayette | 2021 | | 2901 | 13 | 223.15 |
| 18 | Jared Siler | Sr | Neosho | 2022 | | 2178 | 10 | 217.80 |
| 19 | Greg Cain | Sr | Hillsboro | 1991 | | 2825 | 13 | 217.31 |
| 20 | Adam Schwent | Sr | Ste. Genevieve | 2003 | | 2950 | 14 | 210.71 |
| 21 | Brayden James Lidgard | So | West Plains | 2017 | | 2432 | 12 | 202.67 |
| 22 | Tyler Fallert | Jr | Valle Catholic | 2012 | | 3030 | 15 | 202.00 |
| 23 | Keegan Hoopes | Sr | West Plains | 2016 | | 2221 | 11 | 201.91 |
| 24 | Kellen Overstreet | Jr | Penney | 2013 | | 3327 | 17 | 195.71 |
| 25 | Taontae Rainey | Jr | Excelsior Springs | 2018 | | 1920 | 11 | 174.55 |
| 26 | Jerney Jones | Sr | Republic | 2015 | | 1817 | 11 | 165.18 |
| 27 | Isaiah Davis | Sr | Joplin | 2019 | | 2283 | 14 | 163.07 |