| Rank | Student | Grade | School | Year | | G | YDS |
| 1 | Brody McMahon | Sr | Maryville | 2014 | | 13 | 4699 |
| 2 | Kellen Overstreet | Sr | Penney | 2014 | | 14 | 4259 |
| 3 | Gunnar Martin | Sr | Polo | 2015 | | 11 | 3683 |
| 4 | Max Mickey | Sr | Holden | 2012 | | 14 | 3382 |
| 5 | Kellen Overstreet | Jr | Penney | 2013 | | 17 | 3327 |
| 6 | Lee Flood | Sr | Marionville | 2006 | | 14 | 3316 |
| 7 | Lee Flood | Jr | Marionville | 2005 | | 14 | 3272 |
| 8 | Mack J Anderson | Sr | Southwest (Livingston County) | 2019 | | 13 | 3146 |
| 9 | Brad Hocker | So | Archie | 1989 | | 12 | 3094 |
| 10 | Montee Ball | Jr | Timberland | 2007 | | 12 | 3077 |
| 11 | | Sr | Bowling Green | 2023 | | 14 | 3059 |
| 11 | Bleyne Bryant | Sr | Bowling Green | 2023 | | 14 | 3059 |
| 13 | Tyler Fallert | Jr | Valle Catholic | 2012 | | 15 | 3030 |
| 14 | Robbie Allen | Sr | Butler | 1989 | | 13 | 3005 |
| 15 | Adam Schwent | Sr | Ste. Genevieve | 2003 | | 14 | 2950 |
| 16 | Brian Grimes | Sr | Trenton | 1990 | | 11 | 2943 |
| 17 | Garren Vroman | Sr | Fayette | 2021 | | 13 | 2901 |
| 18 | Greg Cain | Sr | Hillsboro | 1991 | | 13 | 2825 |
| 19 | Caleb Schaffitzel | Jr | Fair Grove | 2008 | | 10 | 2759 |
| 20 | Trent Davis | Sr | Wright City | 2010 | | 11 | 2738 |
| 21 | Joshua McNelly | Sr | Norborne | 1996 | | 10 | 2565 |
| 22 | Rayon Simmons | Sr | Christian Brothers College | 2007 | | 10 | 2519 |
| 23 | Marquis Williams | Sr | St. Mary's (St. Louis) | 1992 | | 10 | 2458 |
| 24 | Brayden James Lidgard | So | West Plains | 2017 | | 12 | 2432 |
| 25 | Isaiah Davis | Sr | Joplin | 2019 | | 14 | 2283 |
| 26 | Keegan Hoopes | Sr | West Plains | 2016 | | 11 | 2221 |
| 27 | Jared Siler | Sr | Neosho | 2022 | | 10 | 2178 |
| 28 | Trevor Klein | Jr | East Buchanan | 2022 | | 15 | 2074 |
| 29 | Taontae Rainey | Jr | Excelsior Springs | 2018 | | 11 | 1920 |
| 30 | Jerney Jones | Sr | Republic | 2015 | | 11 | 1817 |