| Rank | Student | Grade | School | Year | | G | YDS |
| 1 | Steven Willhite | Sr | Pattonsburg | 2019 | | 12 | 6175 |
| 2 | Zane Jacoby | Sr | Westran | 2014 | | 15 | 5172 |
| 3 | Dylan Jacob Hair | Sr | Blair Oaks | 2022 | | 14 | 5037 |
| 4 | Kory Faulkner | Sr | Ste. Genevieve | 2008 | | 12 | 4954 |
| 5 | Jordan Webb | Jr | Union | 2007 | | 11 | 4941 |
| 6 | Mack J Anderson | Sr | Southwest (Livingston County) | 2019 | | 13 | 4796 |
| 7 | Zane Reed | Jr | Pattonsburg | 2020 | | 10 | 4794 |
| 8 | Jacob Beckmeyer | Sr | Wellington-Napoleon | 2013 | | 13 | 4755 |
| 9 | T.J. Moe | Sr | Ft. Zumwalt West | 2008 | | 12 | 4586 |
| 10 | Koby Reynolds | Jr | North Nodaway | 2014 | | 12 | 4583 |
| 11 | Eric Humes | Sr | West Platte | 2005 | | 14 | 4399 |
| 12 | Kellen Overstreet | Sr | Penney | 2014 | | 14 | 4344 |
| 13 | Drew Hare | Jr | Ft. Zumwalt West | 2010 | | 13 | 4262 |
| 14 | Sean Ransburg | Sr | Harrisonville | 2007 | | 14 | 4233 |
| 15 | Javan Rae Noyes | Sr | Mid-Buchanan | 2020 | | 14 | 4180 |
| 16 | Jordan Webb | Sr | Union | 2008 | | 12 | 4128 |
| 17 | Jacob Coffey | Jr | Drexel | 2021 | | 13 | 4094 |
| 18 | Cooper Callis | Sr | Jackson | 2017 | 368.18 per game | 11 | 4050 |
| 19 | Javen Rae Noyes | So | Mid-Buchanan | 2018 | | 14 | 4035 |
| 19 | Javen Rae Noyes | So | Mid-Buchanan | 2018 | | 14 | 4035 |
| 21 | T.J. Moe | Jr | Ft. Zumwalt West | 2007 | | 11 | 3823 |
| 22 | Cameron Coffman | Sr | Raymore-Peculiar | 2010 | | 11 | 3739 |
| 23 | Jeff Handy | Sr | Blue Springs | 1989 | | 10 | 3411 |
| 24 | Garren Vroman | Sr | Fayette | 2021 | | 13 | 3350 |