| Rank | Student | Grade | School | Year | | Pts | G | PerG |
| 1 | Mack J Anderson | Sr | Southwest (Livingston County) | 2019 | | 480 | 13 | 36.92 |
| 2 | Caleb Schaffitzel | Jr | Fair Grove | 2009 | | 335 | 11 | 30.45 |
| 3 | Kellen Overstreet | Sr | Penney | 2014 | | 426 | 14 | 30.43 |
| 4 | Connor NIcholas | Sr | West Nodaway | 2008 | | 322 | 11 | 29.27 |
| 5 | Brad Hocker | So | Archie | 1989 | | 324 | 12 | 27.00 |
| 6 | Dylan Haney | Sr | Southwest (Livingston County) | 2010 | | 268 | 10 | 26.80 |
| 7 | Jacob Coffey | Jr | Drexel | 2021 | | 344 | 13 | 26.46 |
| 8 | Caleb Schaffitzel | Sr | Fair Grove | 2010 | | 330 | 13 | 25.38 |
| 9 | Brad Hocker | Sr | Archie | 1991 | | 324 | 13 | 24.92 |
| 10 | Kevin Hunt | Sr | Van Horn (Independence) | 1994 | | 246 | 10 | 24.60 |
| 11 | Dan Kneeshaw | Jr | Branson | 1989 | | 344 | 14 | 24.57 |
| 12 | Brandon Perry | Sr | Boonville | 1999 | | 287 | 12 | 23.92 |
| 13 | Lee Flood | Jr | Marionville | 2005 | | 334 | 14 | 23.86 |
| 14 | Kellen Overstreet | Jr | Penney | 2013 | | 380 | 17 | 22.35 |
| 15 | Lee Flood | Sr | Marionville | 2006 | | 312 | 14 | 22.29 |
| 16 | Garren Vroman | Sr | Fayette | 2021 | | 288 | 13 | 22.15 |
| 17 | Braxton Graha | Sr | Seneca | 2014 | | 326 | 15 | 21.73 |
| 18 | Isaiah Davis | Sr | Joplin | 2019 | | 288 | 14 | 20.57 |
| 18 | Isaiah Davis | Sr | Joplin | 2019 | | 288 | 14 | 20.57 |
| 20 | Andrew Graves | Sr | Jefferson (Festus) | 2018 | | 206 | 11 | 18.73 |
| 21 | Jobe Bryant | Sr | Central (Park Hills) | 2023 | | 240 | 14 | 17.14 |
| 22 | Jerney Jones | Sr | Republic | 2015 | | 176 | 11 | 16.00 |
| 23 | Jobe Bryant | Jr | Central (Park Hills) | 2022 | | 188 | 12 | 15.67 |
| 24 | Dayshawn Welch | Sr | Central (Park Hills) | 2021 | | 176 | 12 | 14.67 |