| Rank | SACK | Student | School | Opponent | Date | |
| 1 | 8 | John Pettit | Fayette | Slater | 11/1/2002 | |
| 2 | 7 | Anthony Fairchild | Van-Far | Missouri Military Academy | 8/29/2014 | |
| 2 | 7 | Gabriel Rubio | Lutheran St. Charles | | 9/13/2019 | |
| 4 | 6 | Torre McMiller | McCluer South-Berkeley | | 9/15/2018 | |
| 4 | 6 | Dominic Bentrup | Rockwood Summit | Parkway West | 11/3/2023 | |
| 6 | 5 | Matt Plattner | Santa Fe | Slater | 11/5/1999 | |
| 6 | 5 | Samuel Weir | Ft. Zumwalt South | Ft. Zumwalt East | 10/9/2015 | |
| 6 | 5 | Justin Lunsford | North Shelby | Northwest (Hughesville) | 9/3/2021 | |
| 6 | 5 | Ty Sidney Atkins | Chaffee | Confluence Prep Academy Charter | 10/4/2024 | |
| 10 | 4.5 | Josh Brown | Francis Howell | Ft. Zumwalt West | 11/11/2011 | |
| 10 | 4.5 | Michael Gette | Bowling Green | North Callaway | 9/4/2015 | |
| 12 | 4 | Jackson Tankersley | Ft. Zumwalt South | Ft. Zumwalt East | 9/2/2022 | |
| 13 | 3.5 | Darius Witherspoon | Blue Springs | Hazelwood East | 11/23/2001 | |
| 13 | 3.5 | Dallas Hecklemann | Owensville | | 9/7/2018 | |
| 15 | 3 | Brandon Vogler | Camdenton | Helias Catholic | 11/27/1999 | |
| 15 | 3 | Billy Beyer | Blue Springs | Hazelwood East | 11/23/2001 | |
| 15 | 3 | Aaron Crawfield | Hickman | Hazelwood East | 11/26/2004 | |
| 15 | 3 | Rodney Dewuan Kelly | Lee's Summit West | Parkway Central | 11/23/2007 | |
| 15 | 3 | T.W. Ayers | Lamar | Lafayette County | 11/24/2017 | Class 2 |
| 15 | 3 | Zach Elam | Staley | Pattonville | 11/25/2017 | Class 5 |
| 15 | 3 | Jaxon Anderson | Worth County | Mound City | 11/24/2018 | 8-Man |
| 15 | 3 | Christopher Skiljan | DeSmet | Raymore-Peculiar | 11/28/2020 | |
| 15 | 3 | Justin Lunsford | North Shelby | Braymer | 10/22/2021 | |
| 15 | 3 | Luke Schwanke | North Shelby | Braymer | 10/22/2021 | |
| 15 | 3 | Luke Schwanke | North Shelby | Knox County | 9/24/2021 | |
| 26 | 2.5 | Brett Spader | North Andrew | South Holt | 11/1/1997 | |
| 26 | 2.5 | Joe Lofland | DeKalb | | 8/30/2019 | |