| Rank | TD | Student | School | Opponent | Date | |
| 1 | 3 | Brannon Carter | Francis Howell North | Poplar Bluff | 9/27/2002 | 95 Ret Yds |
| 1 | 3 | Michael Louis Muehlberger | Blue Springs South | Francis Howell | 10/20/2017 | |
| 3 | 2 | Darren Adkinson | Lexington | Raymore-Peculiar East | 9/3/1982 | |
| 3 | 2 | Joey Semsch | Midway | Gallatin | 11/27/1982 | |
| 3 | 2 | Joey Semsch | Cass-Midway | Gallatin | 11/27/1982 | |
| 3 | 2 | Heath Heckadon | Rich Hill | Jasper | 10/21/1994 | |
| 3 | 2 | David Timmons | Aurora | Lamar | 9/24/2004 | |
| 3 | 2 | Evan Schnicker | Smith-Cotton | Westport | 9/26/2008 | |
| 3 | 2 | Mitchell M Hanson | Parkway North | Parkway Central | 10/23/2009 | |
| 3 | 2 | Cedric Gartman | Lamar | Blair Oaks | 11/24/2012 | |
| 3 | 2 | Cedric Gartman | Lamar | Blair Oaks | 11/24/2012 | |
| 3 | 2 | Nikolas James Gossett | Greenfield | Rich Hill | 10/28/2022 | |