| Rank | INT | Student | School | Opponent | Date | |
| 1 | 5 | Leighton McCabe | Knox County | Schuyler County | 10/28/2011 | |
| 2 | 4 | Mike Kirby | Lexington | Marshall | 9/10/1970 | |
| 2 | 4 | Paul Kummer | Lutheran North | Principia | 10/2/1970 | date? |
| 2 | 4 | Ed Ehrich | Riverview Gardens | Ritenour | 11/1/1972 | |
| 2 | 4 | John Klein | Lutheran North | Berkeley | 11/12/1980 | |
| 2 | 4 | Jim Purcell | O'Hara | St. Pius X (Kansas City) | 11/12/1980 | |
| 2 | 4 | Gary Winn | Westran | Slater | 10/28/1983 | |
| 2 | 4 | Joshua Payne | Concordia | Wentworth Military Academy | 9/17/1999 | |
| 2 | 4 | Austin Eidson | Seneca | Lamar | 9/14/2001 | |
| 2 | 4 | Adam Falloon | Montgomery County | Moberly | 9/14/2001 | All in 1st Half |
| 2 | 4 | Tymon Bay | Cabool | Logan-Rogersville | 9/17/2004 | |
| 2 | 4 | Jacob Forbes | Santa Fe | Windsor | 10/8/2004 | |
| 2 | 4 | Chris Ramire | Harrisonville | Grandview | 10/6/2006 | |
| 2 | 4 | Artemus Jackson | Jennings | Cleveland NJROTC | 9/8/2006 | |
| 2 | 4 | Mark Jones | Eldon | Mexico | 9/8/2006 | |
| 2 | 4 | Trevor Meyer | West Nodaway | Rock Port | 11/11/2014 | |
| 2 | 4 | Beau Brandt | Bowling Green | Clopton | 9/18/2015 | |
| 2 | 4 | Clayton Sweeten | Princeton | | 11/3/2017 | |
| 2 | 4 | Ethan Scott Dayringer | Drexel | Archie | 11/19/2021 | |
| 2 | 4 | Nikolas James Gossett | Greenfield | Rich Hill | 10/28/2022 | |
| 2 | 4 | Graden Pontius | South Callaway | Montgomery County | 10/20/2023 | |
| 22 | 3 | Ted Hoog | Valle Catholic | Rock Port | 11/23/1990 | |
| 22 | 3 | Neal Thompson | Ste. Genevieve | Bolivar | 11/27/1992 | |
| 22 | 3 | Dan Rellergert | St. Vincent | East Buchanan | 11/27/2004 | |
| 22 | 3 | Luke O'Laughlin | South Shelby | Marionville | 11/25/2006 | |
| 22 | 3 | Tyriq Arties | McCluer South-Berkeley | | 9/17/2016 | |
| 22 | 3 | Devin Hardy | Eldon | Fulton | 8/26/2022 | |
| 22 | 3 | Kaden Sutton | Archie | Worth County | 11/30/2023 | 8-Man |
| 29 | 2 | James Walker and Miles Jumps | Mound City | St. Joseph Christian | 11/1/2000 | |
| 29 | 2 | Hunter M. Scaggs | Mid-Buchanan | Maysville | 8/28/2015 | |
| 29 | 2 | Hunter M. Scaggs | Mid-Buchanan | East Buchanan | 10/28/2016 | |
| 29 | 2 | Hunter M. Scaggs | Mid-Buchanan | Princeton | 8/18/2017 | |
| 29 | 2 | Reed J. Black | Mid-Buchanan | East Buchanan | 10/20/2017 | |
| 29 | 2 | Drew Allen Russell | Mid-Buchanan | North Platte | 9/20/2018 | |
| 29 | 2 | Travis James Runyan | Mid-Buchanan | East Buchanan | 11/2/2018 | |
| 29 | 2 | Lane Griffith Ellison | Mid-Buchanan | Maysville | 9/6/2019 | |
| 29 | 2 | Austin Wilkerson | Lamar | St. Pius X (Kansas City) | 12/4/2020 | |