| Rank | YDS | Student | School | Opponent | Date | |
| 1 | 742 | Harrison Andrew Smith | Princeton | Polo | 10/14/2016 | |
| 2 | 719 | Zane Reed | Pattonsburg | St. Paul Lutheran (Concordia) | 10/16/2020 | |
| 3 | 673 | Alex Huston | Glendale | West Plains | 9/4/2015 | |
| 4 | 667 | T. J. Moe | Ft. Zumwalt West | Jefferson City | 10/24/2008 | |
| 5 | 652 | Stephen Talbert | Clopton/Elsberry | Montgomery County | 9/25/2015 | |
| 6 | 644 | Steven Willhite | Pattonsburg | | 10/4/2019 | vs. Rich Hill |
| 7 | 632 | Jake Harlan | St. James | Owensville | 10/27/2011 | |
| 8 | 628 | Alex Huston | Glendale | Rolla | 10/2/2015 | |
| 9 | 610 | Cole Dilley | Pattonsburg | Braymer | 8/25/2017 | |
| 10 | 597 | Dallas Bo Dean | School of the Osage | Logan-Rogersville | 10/31/2012 | |
| 11 | 589 | Alex Huston | Glendale | Waynesville | 10/9/2015 | |
| 11 | 589 | Aidan McDaniel | Francis Howell North | Francis Howell Central | 9/26/2016 | |
| 13 | 583 | Jordan Webb | Union | Hermann | 9/21/2007 | |
| 14 | 570 | Paxton Joseph Delaurent | Camdenton | Rolla | 10/12/2018 | |
| 15 | 526 | Paxton Joseph Delaurent | Camdenton | Webb City | 12/2/2019 | |
| 16 | 513 | Casen Murphy | Central (Park Hills) | Central (Park Hills) | 12/1/2023 | |
| 16 | 513 | Casen Murphy | Central (Park Hills) | Seneca | 12/1/2023 | |
| 18 | 494 | Preston Hatfield | Lee's Summit | Nixa | 12/6/2025 | Class 6 |
| 19 | 468 | Dylan Hair | Blair Oaks | Maryville | 12/5/2020 | |
| 20 | 455 | Skylar John Thompson | Fort Osage | Chaminade | 11/28/2015 | |
| 21 | 453 | Tommy Corwin | DeSmet | Hazelwood Central | 11/25/2005 | |
| 22 | 436 | Drew Newhart | Cameron | Montgomery County | 11/25/2005 | |
| 23 | 412 | Thomas Militello | MICDS | Webb City | 11/25/2011 | |
| 24 | 399 | Nate Minnis | Blue Springs | Parkway Central | 11/28/1992 | |
| 25 | 373 | Darrell Jackson | Webster Groves | Raymore-Peculiar | 11/20/2002 | |