| Rank | Student | School | Opponent | Date | | YDS | ATT | Total |
| 1 | Todd Joseph Simpson | Camdenton | Parkview | 9/15/2017 | | 228 | 4 | 57.00 |
| 2 | Marcus Starks | Bowling Green | Van-Far | 8/27/2021 | | 278 | 5 | 55.60 |
| 3 | Mack J Anderson | Southwest (Livingston County) | | 9/27/2019 | | 203 | 4 | 50.75 |
| 4 | Brandon Bourbon | Potosi | North County | 10/2/2009 | | 451 | 9 | 50.11 |
| 5 | Bradley P Allen | Jefferson City | Hickman | 10/31/2008 | | 401 | 9 | 44.56 |
| 6 | Scott Concannon | Rock Bridge | Hickman | 9/13/2006 | at Faurot | 324 | 8 | 40.50 |
| 7 | Colby Matthew Ott | Jefferson (Festus) | | 10/5/2018 | vs. Grandview | 229 | 6 | 38.17 |
| 8 | Amos Fredrickson | North Shelby | Brunswick | 9/30/2022 | | 150 | 4 | 37.50 |
| 9 | Jordan Shockley | Jefferson (Festus) | Grandview (Hillsboro) | 10/2/2015 | | 216 | 6 | 36.00 |
| 10 | Austin Graves | Jefferson (Festus) | Herculaneum | 9/4/2015 | | 358 | 10 | 35.80 |
| 11 | | Chaffee | Doniphan | 10/14/2022 | | 317 | 9 | 35.22 |
| 11 | Carson Kelly Spies | Chaffee | Doniphan | 10/14/2022 | | 317 | 9 | 35.22 |
| 13 | Chad Shockley | St. James | Southern Boone | 10/14/2005 | | 417 | 12 | 34.75 |
| 14 | Ryder Easton Ross | Strafford | Buffalo | 9/20/2024 | | 309 | 9 | 34.33 |
| 15 | Caleb Schaffitzel | Fair Grove | Ash Grove | 10/16/2009 | | 271 | 8 | 33.88 |
| 16 | Javis Vineyard | Clark County | Milan | 8/29/2008 | | 267 | 8 | 33.38 |
| 17 | Kevin Richard Belk | Sherwood | Maranatha Academy (KS) | 9/19/2008 | | 194 | 6 | 32.33 |
| 18 | De’Andre Vandevender | Trenton | Schuyler County | 11/3/2006 | | 310 | 10 | 31.00 |
| 19 | Justin Lunsford | North Shelby | Braymer | 10/22/2021 | | 272 | 9 | 30.22 |
| 20 | Garren Vroman | Fayette | Paris | 10/1/2021 | | 347 | 13 | 26.69 |
| 21 | Jayden Ivey | Lebanon | Hillcrest | 10/19/2018 | | 155 | 6 | 25.83 |
| 22 | Amos Fredrickson | North Shelby | Knox County | 9/23/2022 | | 215 | 10 | 21.50 |
| 23 | Garhett Maddox Cardwell | Sherwood | Sherwood | 10/13/2023 | | 315 | 29 | 10.86 |