| Rank | YDS | Student | School | Opponent | Date | |
| 1 | 559 | Gunnar Martin | Polo | Maysville | 9/25/2015 | |
| 2 | 533 | Rayon Simmons | Christian Brothers College | Parkway South | 11/2/2007 | |
| 3 | 522 | Austin Jones | Orrick | Windsor | 10/3/2003 | |
| 4 | 515 | Jamarion Smith | Portageville | Scott City | 11/4/2022 | |
| 5 | 508 | Blane Boss | Windsor (Imperial) | Hillsboro | 9/19/2003 | |
| 6 | 474 | Gabriel L Fields | Central (St. Joseph) | Excelsior Springs | 10/18/2024 | |
| 7 | 463 | Mario Whitney | Jackson | Parkway North | 9/28/2001 | |
| 8 | 455 | Evan Williams | Mountain Grove | Liberty (Mountain View) | 9/12/2008 | |
| 9 | 451 | Brandon Bourbon | Potosi | North County | 10/2/2009 | |
| 10 | 448 | Bryce Enyard | Westran | Paris | 9/11/2009 | |
| 10 | 448 | Kade Kennedy | Plattsburg | North Platte | 10/20/2017 | |
| 12 | 447 | Jerney E Jones | Republic | Glendale | 10/30/2015 | |
| 13 | 445 | Andrew Graves | Jefferson (Festus) | St. Vincent | 10/16/2015 | |
| 14 | 425 | Talan Holt | Princeton | Princeton | 9/8/2023 | vs Polo |
| 14 | 425 | Talan Holt | Princeton | Princeton | 9/8/2023 | |
| 16 | 423 | Jamarcus Cody | Excelsior Springs | | 10/15/2011 | |
| 17 | 420 | Willie Williams | McCluer South-Berkeley | Trinity Catholic | 10/4/2008 | |
| 18 | 417 | Jerney Jones | Republic | Glendale | 10/30/2015 | |
| 19 | 410 | Wade Cooper | Schuyler County | | 9/27/2019 | |
| 20 | 403 | Jaxon Miller | Orrick | Braymer | 9/16/2022 | 8-man |
| 21 | 394 | Tariq A Garner | Monroe City | Louisiana | 10/11/2013 | |
| 22 | 386 | | St. Pius X (Festus) | St. Pius X (Festus) | 10/27/2023 | |
| 23 | 381 | Dayshawn Welch | Central (Park Hills) | Northwest (Cedar Hill) | 9/11/2020 | |
| 24 | 379 | Tyler Friend | Central (Park Hills) | Central (New Madrid County) | 10/9/2009 | |
| 24 | 379 | Keegan Hoopes | West Plains | Parkview | 10/7/2016 | |
| 26 | 368 | Brayden James Lidgard | West Plains | Rolla | 10/13/2017 | |
| 27 | 367 | Blake Buchanan | Orrick | Braymer | 9/17/2021 | |
| 28 | 359 | Brayden James Lidgard | West Plains | Kickapoo | 9/29/2017 | |
| 29 | 347 | | Fayette | Paris | 10/1/2021 | |
| 29 | 347 | Garren Vroman | Fayette | Paris | 10/1/2021 | |
| 31 | 323 | Brock West | Lebanon | Camdenton | 9/7/2012 | |
| 31 | 323 | Taontae Rainey | Excelsior Springs | | 10/5/2018 | |
| 33 | 322 | Garren Vroman | Fayette | Harrisburg | 11/5/2021 | |
| 34 | 319 | John Berry | Lebanon | Parkview | 10/14/2016 | |
| 35 | 317 | Carson Kelly Spies | Chaffee | Doniphan | 10/14/2022 | |
| 36 | 315 | Garhett Maddox Cardwell | Sherwood | Russellville | 10/13/2023 | |
| 37 | 314 | Elza Evans | Lebanon | Rolla | 8/22/2014 | |
| 37 | 314 | Taontae Rainey | Excelsior Springs | | 9/21/2018 | |
| 39 | 313 | Collin Nichols | Troy Buchanan | Troy Buchanan | 9/28/2018 | |
| 40 | 311 | Amos Fredrickson | North Shelby | St. Paul Lutheran (Concordia) | 10/7/2022 | |
| 41 | 302 | Logan Horton | Chaffee | Veritas Christian HS | 10/11/2024 | |
| 42 | 291 | Tim Sybert | North Andrew | Fairfax | 11/1/1996 | 8-Man |
| 43 | 289 | Kyren Williams | Vianney | Fort Osage | 12/1/2018 | Class 5 |
| 44 | 286 | Garren Vroman | Fayette | Father Tolton Regional Catholic | 10/15/2021 | |
| 45 | 285 | Garhett Cardwell | Sherwood | Versailles | 10/20/2023 | |
| 46 | 284 | Evan Urhahn | Kelly | | 10/5/2018 | |
| 47 | 283 | Hayden Ecker | North Andrew | Northland Christian HS | 9/17/2021 | |
| 48 | 280 | Tae'Sean Trinell McShane | Central (Springfield) | Clever | 8/26/2022 | |
| 49 | 278 | Enrique Padron | Missouri Military Academy | Crystal City | 10/16/2020 | |
| 50 | 276 | Justin McElroy | St. Joseph Christian | Worth County | 11/1/2006 | |
| 51 | 272 | Justin Lunsford | North Shelby | Braymer | 10/22/2021 | |
| 52 | 267 | Erich Bauman | Valle Catholic | Mt. Vernon | 11/27/1982 | |
| 53 | 266 | Tim Sybert | North Andrew | South Holt | 11/1/1997 | |
| 54 | 263 | Carson Spies | Chaffee | Malden | 9/16/2022 | |
| 55 | 262 | Tyler Fallert | Valle Catholic | Penney | 11/23/2012 | |
| 56 | 261 | Lee Flood | Marionville | West Platte | 11/26/2005 | |
| 57 | 260 | Mike Arnold | Monett | South Shelby | 11/27/1991 | |
| 58 | 259 | Garren Vroman | Fayette | Sweet Springs | 11/12/2021 | |
| 59 | 255 | Jake Bain | John Burroughs | Odessa | 11/28/2015 | |
| 60 | 254 | Dan Kneeshaw | Branson | Lutheran North | 11/24/1989 | |
| 60 | 254 | Levi Petersen | Lamar | Blair Oaks | 11/24/2012 | |
| 62 | 250 | Garren Vroman | Fayette | Harrisburg | 10/8/2021 | |
| 63 | 248 | Elijah Lee Mullock | Worth County | Mound City | 11/1/2011 | |
| 63 | 248 | Gabriel Day | Lexington | Knob Noster | 10/4/2024 | |
| 65 | 243 | Garren Vroman | Fayette | Slater | 10/22/2021 | |
| 66 | 232 | Evan Urhahn | Kelly | | 8/25/2017 | Crystal City |
| 67 | 227 | Trevor Klein | East Buchanan | Gallatin | 11/19/2022 | |
| 68 | 222 | Evan Urhahn | Kelly | | 10/19/2018 | |
| 69 | 217 | Travis James Runyan | Mid-Buchanan | Adrian | 11/28/2020 | |
| 70 | 216 | Garren Vroman | Fayette | Salisbury | 10/8/2021 | |
| 71 | 211 | Derek Sybert | North Andrew | Mound City | 11/1/1999 | |
| 72 | 206 | Gavin Wyatt | Crest Ridge | Wellington-Napoleon | 9/1/2023 | |
| 73 | 202 | Javan Rae Noyes | Mid-Buchanan | Plattsburg | 10/5/2018 | |