| Rank | Pts | Student | School | Opponent | Date | |
| 1 | 84 | Jaxon Miller | Orrick | Braymer | 9/16/2022 | 8 man |
| 2 | 66 | Stephen Talbert | Clopton | Montgomery County | 9/25/2015 | |
| 3 | 64 | Blake Buchanan | Orrick | Braymer | 9/17/2021 | |
| 4 | 62 | Aaron Johnson | Lincoln College Prep | Northeast (Kansas City) | 11/2/1985 | |
| 5 | 60 | Jake Harlan | St. James | Owensville | 10/27/2011 | |
| 6 | 58 | Austin Jones | Orrick | Windsor | 9/28/2001 | |
| 6 | 58 | Kaeden Jenkins | Bowling Green | Clopton | 9/18/2015 | |
| 8 | 54 | Jared Rennick | Washington | Holt | 10/9/2015 | |
| 8 | 54 | Peyton Jones | Pattonsburg | Braymer | 8/25/2017 | |
| 10 | 52 | Trevor Meyer | West Nodaway | Worth County | 10/31/2014 | |
| 10 | 52 | Enrique Padron | Missouri Military Academy | Crystal City | 10/16/2020 | |
| 12 | 50 | Trevor Meyer | West Nodaway | Worth County | 9/6/2013 | |
| 12 | 50 | Wyatt Ellis | Owensville | Eldon | 8/25/2017 | |
| 12 | 50 | Isaiah Merida | Eldon | Owensville | 8/25/2017 | |
| 12 | 50 | Hayden Ecker | North Andrew | Northland Christian HS | 9/17/2021 | |
| 16 | 48 | Elijah Lee Mullock | Worth County | Mound City | 3/1/2011 | |
| 17 | 44 | Jerney Jones | Republic | Glendale | 10/30/2015 | |
| 18 | 42 | Garren Vroman | Fayette | Salisbury | 10/15/2021 | |
| 19 | 40 | Jonathan Schoonover | Worth County | North Andrew | 3/1/1999 | |
| 19 | 40 | Jobe Bryant | Central (Park Hills) | Central (Park Hills) | 12/1/2023 | 6 TDs, 2 2 pt |
| 19 | 40 | Jobe Bryant | Central (Park Hills) | Seneca | 12/1/2023 | |
| 22 | 38 | Justin McElroy | St. Joseph Christian | Worth County | 3/1/2006 | |
| 23 | 36 | Zach Sharp | Mound City | North Andrew | 3/1/2003 | |
| 24 | 32 | Garren Vroman | Fayette | Slater | 9/10/2021 | |
| 25 | 30 | Derrick Washington | Raymore-Peculiar | Kirkwood | 11/1/2006 | |
| 25 | 30 | Evan Urhahn | Kelly | | 10/19/2018 | |
| 25 | 30 | Dayshawn Welch | Central (Park Hills) | Central (Park Hills) | 9/17/2021 | |
| 25 | 30 | Garren Vroman | Fayette | Paris | 10/1/2021 | |
| 25 | 30 | Logan Horton | Chaffee | Veritas Christian HS | 10/11/2024 | |
| 30 | 29 | Kris Saathoff | Adrian | Hayti | 11/1/2002 | |
| 31 | 28 | Joey Semsch | Cassville | Gallatin | 11/1/1982 | |
| 31 | 28 | Joey Semsch | Midway | | 11/1/1982 | |
| 31 | 28 | Tony Martin | Central (Park Hills) | Central (Park Hills) | 10/31/2008 | |
| 31 | 28 | Tyler Friend | Central (Park Hills) | Central (Park Hills) | 10/9/2009 | |