| Rank | Student | School | Opponent | Date | | H | Pts |
| 1 | Mack J Anderson | Southwest (Livingston County) | | 10/11/2019 | | 1 | 52 |
| 2 | Hayden Ecker | North Andrew | Northland Christian HS | 9/17/2021 | | 1 | 50 |
| 3 | Kaeden Jenkins | Bowling Green | Clopton | 9/18/2015 | | 1 | 48 |
| 4 | Blake Buchanan | Orrick | Braymer | 9/17/2021 | | 1 | 46 |
| 4 | Jaxon Miller | Orrick | Braymer | 9/16/2022 | 8 man | 2 | 46 |
| 6 | Kellen Overstreet | Penney | Mid-Buchanan | 9/12/2014 | | 1 | 44 |
| 7 | Germaine Race | Warrensburg | Van Horn (Independence) | 9/27/2002 | 7 rush TD | 1 | 42 |
| 8 | Dallas Bo Dean | Osage | Warsaw | 10/19/2012 | 6 TDs, 4 PATs | 1 | 40 |
| 9 | Lee Flood | Marionville | Miller | 10/21/2005 | 6 TDs, 1 2Pt | 1 | 38 |
| 9 | Enrique Padron | Missouri Military Academy | Crystal City | 10/16/2020 | | 1 | 38 |
| 9 | Luke Gall | Carthage | Republic | 8/26/2022 | | 1 | 38 |
| 12 | Jared Rennick | Washington | Holt | 10/9/2015 | | | 36 |
| 12 | Andrew Graves | Jefferson (Festus) | | 10/5/2018 | | 36 | 36 |
| 12 | Travis James Runyan | Mid-Buchanan | Adrian | 11/28/2020 | | 1 | 36 |
| 15 | Kevin Baisch | DeSoto | Pacific | 9/3/2004 | | 1 | 34 |
| 15 | Peyton Jones | Pattonsburg | Braymer | 8/25/2017 | 5 TDs, 2 2PTs | 1 | 34 |
| 17 | Jared Hicks | Willow Springs | Ava | 9/13/2002 | 5 TDs, 2 PATs | 1 | 32 |
| 18 | Tommy Saunders | Kearney | O'Hara | 9/5/2003 | | 1 | 30 |
| 18 | Chad Shockley | St. James | Hermann | 9/10/2004 | 5 TDs, 2 PATs | 1 | 30 |
| 18 | Justin Thornton | Central (St. Joseph) | Oak Park | 9/17/2004 | 5 TDs | 1 | 30 |
| 18 | Jocelyn Jones | Kirkwood | Vianney | 10/21/2005 | 5 TDs | 1 | 30 |
| 18 | Ethan H. Harris | South Shelby | Paris | 10/26/2007 | 5 TDs | 1 | 30 |
| 18 | Tyler Fisher | Seckman | Windsor (Imperial) | 10/2/2009 | 5 TDs | 1 | 30 |
| 18 | Nathan Adams | John Burroughs | Imagine College Prep Charter | 10/23/2010 | | | 30 |
| 18 | Daniel Morris | Ft. Zumwalt East | Washington | 10/2/2015 | | | 30 |
| 26 | Jobe Bryant | Central (Park Hills) | Seneca | 12/1/2023 | | 1 | 26 |
| 27 | Jobe Bryant | Central (Park Hills) | Central (Park Hills) | 12/1/2023 | | 1 | 24 |