| Rank | Student | School | Years | | YDS | G | PerG |
| 1 | Steven Willhite | Pattonsburg | 2016-2019 | | 10195 | 25 | 407.80 |
| 2 | Eric Czerniewski | Montgomery County | 2003-2005 | | 11557 | 36 | 321.03 |
| 3 | Jordan Webb | Union | 2006-2008 | | 10533 | 34 | 309.79 |
| 4 | Paxton Joseph Delaurent | Camdenton | 2018-2019 | | 7892 | 26 | 303.54 |
| 4 | Paxton Joseph Delaurent | Camdenton | 2018-2019 | | 7892 | 26 | 303.54 |
| 6 | Cooper Callis | Jackson | 2014-2017 | | 7651 | 28 | 273.25 |
| 7 | Koby Reynolds | North Nodaway | 2012-2015 | | 11610 | 43 | 270.00 |
| 8 | Logan Twehous | Rock Bridge | 2012-2014 | | 8754 | 35 | 250.11 |
| 9 | Kory Faulkner | Ste. Genevieve | 2006-2008 | | 8637 | 35 | 246.77 |
| 10 | Derek Duncan | Montgomery County | 2000-2002 | | 7591 | 31 | 244.87 |
| 11 | Drew Hare | Ft. Zumwalt West | 2010-2011 | | 5868 | 25 | 234.72 |
| 12 | Drew Lock | Lee's Summit | 2012-2014 | | 7021 | 30 | 234.03 |
| 13 | Lawson Beem | Skyline | 2018-2021 | | 8261 | 37 | 223.27 |
| 14 | Jacob Beckemeyer | Wellington-Napoleon | 2010-2012 | | 8861 | 40 | 221.53 |
| 15 | Cael Welker | Jackson | 2018-2020 | | 8594 | 39 | 220.36 |
| 16 | Robert Hunter | Father Tolton Regional Catholic | 2016-2018 | | 6225 | 29 | 214.66 |
| 17 | Eric Humes | West Platte | 2003-2005 | | 7016 | 34 | 206.35 |
| 18 | Drew Newhart | Cameron | 2002-2005 | | 8993 | 44 | 204.39 |
| 19 | Jeff Handy | Blue Springs | 1987-1989 | | 6130 | 30 | 204.33 |
| 20 | Dylan Jacob Hair | Blair Oaks | 2019-2022 | | 10782 | 53 | 203.43 |
| 21 | Justin Lamoine Baker | Lutheran North | 2011-2014 | | 7737 | 40 | 193.43 |
| 22 | Blake Tash | Joplin | 2017-2019 | | 6591 | 37 | 178.14 |
| 22 | | Joplin | 2017-2019 | | 6591 | 37 | 178.14 |
| 24 | Javan Rae Noyes | Mid-Buchanan | 2017-2020 | | 9043 | 52 | 173.90 |
| 25 | Corbin Berkstresser | Lee's Summit | 2007-2010 | | 6060 | 35 | 173.14 |
| 26 | Josey Dalton Meierarend | Odessa | 2016-2019 | | 7299 | 43 | 169.74 |
| 27 | Adam Hinspeter | Centralia | 2000-2003 | | 7109 | 45 | 157.98 |