| Rank | Student | School | Years | | G | YDS |
| 1 | Koby Reynolds | North Nodaway | 2012-2015 | | 43 | 11610 |
| 2 | Eric Czerniewski | Montgomery County | 2003-2005 | | 36 | 11557 |
| 3 | Dylan Jacob Hair | Blair Oaks | 2019-2022 | | 53 | 10782 |
| 4 | Jordan Webb | Union | 2006-2008 | | 34 | 10533 |
| 5 | Steven Willhite | Pattonsburg | 2016-2019 | | 25 | 10195 |
| 6 | Javan Rae Noyes | Mid-Buchanan | 2017-2020 | | 52 | 9043 |
| 7 | Drew Newhart | Cameron | 2002-2005 | | 44 | 8993 |
| 8 | Jacob Beckemeyer | Wellington-Napoleon | 2010-2012 | | 40 | 8861 |
| 9 | Logan Twehous | Rock Bridge | 2012-2014 | | 35 | 8754 |
| 10 | Kory Faulkner | Ste. Genevieve | 2006-2008 | | 35 | 8637 |
| 11 | Cael Welker | Jackson | 2018-2020 | | 39 | 8594 |
| 12 | Jack Behl | Lafayette (Wildwood) | 2022-2024 | | 35 | 8582 |
| 13 | Lawson Beem | Skyline | 2018-2021 | | 37 | 8261 |
| 14 | Paxton Joseph Delaurent | Camdenton | 2018-2019 | | 26 | 7892 |
| 15 | Justin Lamoine Baker | Lutheran North | 2011-2014 | | 40 | 7737 |
| 16 | Cooper Callis | Jackson | 2014-2017 | | 28 | 7651 |
| 17 | Derek Duncan | Montgomery County | 2000-2002 | | 31 | 7591 |
| 18 | Josey Dalton Meierarend | Odessa | 2016-2019 | | 43 | 7299 |
| 19 | Gavin Johnston | Mt. Vernon | 2021-2024 | | 39 | 7219 |
| 20 | Adam Hinspeter | Centralia | 2000-2003 | | 45 | 7109 |
| 21 | Brayden Matheney | Hallsville | 2021-2024 | | 27 | 7059 |
| 22 | Drew Lock | Lee's Summit | 2012-2014 | | 30 | 7021 |
| 23 | Eric Humes | West Platte | 2003-2005 | | 34 | 7016 |
| 24 | Blake Tash | Joplin | 2017-2019 | | 37 | 6591 |
| 25 | Robert Hunter | Father Tolton Regional Catholic | 2016-2018 | | 29 | 6225 |
| 26 | Jeff Handy | Blue Springs | 1987-1989 | | 30 | 6130 |
| 27 | Corbin Berkstresser | Lee's Summit | 2007-2010 | | 35 | 6060 |
| 28 | Drew Hare | Ft. Zumwalt West | 2010-2011 | | 25 | 5868 |