| Rank | YDS | Student | School | Opponent | Date | |
| 1 | 107 | Jack Delane Michaud | St. Pius X (Festus) | Caruthersville | 9/30/2024 | |
| 2 | 105 | Ryan Ruble | Grandview (Hillsboro) HS | St. Vincent | 10/15/2021 | |
| 3 | 103 | Carlton Fowler | Windsor | Slater | 10/6/2017 | |
| 4 | 102 | Dariyan R Williams-Reaves | Lexington | Southeast | 9/15/2023 | |
| 5 | 100 | Robin Black | Brookfield | South Shelby | 9/18/1970 | |
| 5 | 100 | Steve Reeves | Glendale | Hillcrest | 10/6/1977 | |
| 5 | 100 | Matt Daspit | Neosho | Republic | 10/24/1977 | |
| 5 | 100 | Darrell Brooks | Lexington | John B. Lange | 11/29/1980 | |
| 5 | 100 | Darrell Brooks | Lexington | John Burroughs | 11/29/1980 | |
| 5 | 100 | Tom Hampton | Hardin-Central | Braymer | 9/29/1989 | |
| 5 | 100 | Jason Bush | Pattonville | Hazelwood Central | 11/8/1995 | at Ritenour |
| 5 | 100 | Scott Crall | Oak Grove | Booneville | 9/1/1995 | date? |
| 5 | 100 | Sean Hedrick | Brookfield | Scotland County | 10/9/1998 | |
| 5 | 100 | Michael Clark | Neosho | Nevada | 10/22/1999 | |
| 5 | 100 | Monroe Hicks | Central (Cape Girardeau) | Farmington | 11/2/2000 | |
| 5 | 100 | Greg Nutter | Clark County | Schuyler County | 10/5/2001 | |
| 5 | 100 | Steve Scanlon | Hillsboro | DeSoto | 9/17/2004 | |
| 5 | 100 | Sean O’Toole | Brookfield | Cameron | 11/10/2004 | |
| 5 | 100 | Cody Morgenstern | Knox County | Westran | 9/21/2007 | |
| 5 | 100 | Ryan Cooper | Owensville | Union | 10/12/2007 | |
| 5 | 100 | Tanner Mckenzie Thompson | Glendale | Parkview | 10/19/2007 | |
| 5 | 100 | Keaton Ebersold | King City | Maysville | 10/28/2010 | |
| 5 | 100 | Donavin Newsom | Parkway North | St. Louis University | 8/26/2011 | |
| 5 | 100 | Devin-Michael Griffin | Parkway North | Webster Groves | 10/2/2015 | |
| 5 | 100 | Andrew Montemayor | Mt. Vernon | Reeds Spring | 8/19/2016 | |
| 5 | 100 | Lucas Waterworth | Wellington-Napoleon | Lone Jack | 9/18/2020 | |
| 27 | 99 | Preston Smith | El Dorado Springs | Clever | 9/3/2021 | |
| 28 | 95 | Cedric Gartman | Lamar | Blair Oaks | 11/24/2012 | |
| 29 | 88 | Kevin Gilgour | Chillicothe | Herculaneum | 11/29/1991 | |
| 30 | 83 | Tommy Saunders | Kearney | Ladue Horton Watkins | 11/28/2003 | |
| 31 | 82 | Ted Hoog | Valle Catholic | Rock Port | 11/23/1990 | |
| 32 | 80 | Josh Owens | Mound City | St. Joseph Christian | 11/26/2010 | |