| Rank | YDS | Student | School | Opponent | Date | |
| 1 | 100 | Joe Lawton | St. Louis University | Beaumont | 11/27/1948 | |
| 1 | 100 | Scott Spencer | Glendale | Springdale, AR | 9/3/1976 | |
| 1 | 100 | James Hawkins | Parkway North | Parkway West | 10/8/2010 | |
| 1 | 100 | Isaiah Kadeem Holman | Lutheran North | John Burroughs | 9/21/2013 | |
| 5 | 99 | Matt Fisher | McDonald County | Carthage | 10/20/2000 | |
| 5 | 99 | David Poolman | Platte County | Odessa | 11/12/2001 | |
| 5 | 99 | Garrett Hulsey | Sullivan | Union | 10/4/2002 | |
| 5 | 99 | Chad Shcokley | St. James | Pacific | 10/2/2003 | |
| 5 | 99 | Seth Hedrick | Waynesville | Parkview | 9/12/2014 | |
| 5 | 99 | Brock Wood | South Shelby | | 9/21/2018 | Clark County |
| 5 | 99 | Martez Manuel | Rock Bridge | | 9/28/2018 | |
| 5 | 99 | Brayden Burleson | Mid-Buchanan | Princeton | 8/30/2019 | |
| 5 | 99 | Max A Kates | Lee's Summit | Lee's Summit North | 9/15/2023 | |
| 5 | 99 | Preston R Hatfield | Lee's Summit | Oak Park | 9/29/2023 | |
| 15 | 96 | Matt Angell | Owensville | Harrisonville | 11/25/2006 | |
| 16 | 95 | Pat Brown | Hazelwood Central | Rockhurst | 11/28/1981 | |
| 17 | 93 | Bryley Dale Ray | Odessa | | 12/7/2019 | |
| 18 | 92 | Kris Saathoff | Adrian | Hayti | 11/20/2002 | |
| 19 | 91 | David Poolman | Platte County | Central (New Madrid County) | 11/23/2001 | |
| 20 | 88 | James Williams | Lafayette County | Lamar | 11/25/2011 | |
| 21 | 74 | Derek Sybert | North Andrew | Mound City | 11/20/1999 | 8-Man |