| Rank | YDS | Student | School | Opponent | Date | |
| 1 | 99 | Steve Levingston | Aurora | Lamar | 10/20/1978 | |
| 1 | 99 | Chris Brown | Carthage | Harrisonville | 10/31/1997 | |
| 1 | 99 | Dan Dodson | North County Christian Sr | Potosi | 10/31/1997 | |
| 1 | 99 | William Franklin | Vashon | DeSmet | 9/6/2003 | |
| 1 | 99 | Tyrone Brown | Riverview Gardens | Ritenour | 11/1/2003 | |
| 1 | 99 | Trent Wilson | Seneca | East Newton | 10/7/2005 | |
| 1 | 99 | Adam Hawkinson | Washington | Warrenton | 10/8/2010 | |
| 1 | 99 | Gavin Wright | Potosi | North County Christian Sr | 10/18/2013 | |
| 1 | 99 | Trevon Alexander | Richmond | Maryville | 11/4/2016 | |
| 1 | 99 | Dylan Schroeder | Highland | | 10/11/2019 | |
| 1 | 99 | Payton Matthews | Ste. Genevieve | Kennett | 11/6/2020 | |
| 12 | 98 | Joe Hendrix | East Prairie | Chaffee | 10/11/1991 | |
| 12 | 98 | Derek Andrew Vanlandingham | Paris | Salisbury | 10/12/2007 | |
| 12 | 98 | Brandon Bourbon | Potosi | St. Francis Borgia | 10/5/2007 | |
| 15 | 94 | Holden Strain | Rockwood Summit | Parkway West | 10/20/2023 | |
| 16 | 93 | Daniel Hopkins | Rockwood Summit | Marquette | 8/18/2017 | |
| 17 | 86 | Chase Allen-Jackman | Fayette | Paris | 9/30/2022 | |
| 18 | 74 | Mason Gastel | Lamar | St. Pius X (Kansas City) | 12/4/2020 | |
| 19 | 72 | Cody King | Miami | Worth County | 11/17/2001 | |
| 20 | 68 | Dylan Witherspoon | Windsor | Mid-Buchanan | 12/5/2020 | |
| 21 | 65 | Zach Allee | Worth County | St. Joseph Christian | 11/18/2006 | |