| Rank | TD | Student | School | Opponent | Date | |
| 1 | 11 | Jaxon Miller | Orrick | Braymer | 9/16/2022 | 8 man |
| 2 | 10 | Blake Buchanan | Orrick | Braymer | 9/17/2021 | |
| 2 | 10 | Blake Buchanan | Orrick | Braymer | 9/17/2021 | |
| 4 | 9 | Jared Rennick | Washington | Holt | 10/9/2015 | |
| 4 | 9 | Ryder Wilckens-Abney | Concordia | Braymer | 10/8/2021 | |
| 6 | 8 | Austin Jones | Orrick | Windsor | 9/28/2001 | |
| 6 | 8 | Austin JoneS | Orrick | Windsor | 10/3/2003 | |
| 6 | 8 | Chad Shockley | St. James | Southern Boone | 10/14/2005 | |
| 6 | 8 | Kaeden Jenkins | Bowling Green | Clopton | 9/18/2015 | |
| 6 | 8 | Stephen Talbert | Clopton/Elsberry | Montgomery County | 9/25/2015 | |
| 6 | 8 | Peyton Jones | Pattonsburg | Braymer | 8/25/2017 | receiving |
| 6 | 8 | Hayden Ecker | North Andrew | Northland Christian HS | 9/17/2021 | |
| 6 | 8 | Richard Eric Woodhouse | Skyline | Agape Boarding School | 8/26/2022 | |
| 6 | 8 | Quenton Hughes | Neosho | Willard | 8/26/2022 | |
| 15 | 7 | Elijah Lee Mullock | Worth County | Mound City | 11/1/2011 | |
| 15 | 7 | Jerney Jones | Republic | Glendale | 10/15/2015 | |
| 15 | 7 | Skylar John Thompson | Fort Osage | Chaminade | 11/28/2015 | |
| 15 | 7 | Darain Horr | DeKalb | | 8/21/2015 | |
| 15 | 7 | Keegan Hoopes | West Plains | West Plains | 10/7/2016 | vs. Parkview |
| 15 | 7 | Keegan Hoopes | West Plains | Parkview | 10/7/2016 | |
| 15 | 7 | Enrique Padron | Missouri Military Academy | Crystal City | 10/16/2020 | |
| 15 | 7 | Jake Tagtmeyer | Concordia | Santa Fe | 9/24/2021 | |
| 15 | 7 | Sammy Lee Bryant | Caruthersville | Caruthersville | 10/10/2025 | |
| 24 | 6 | Derek Sybert | North Andrew | Mound City | 11/1/1999 | |
| 24 | 6 | Jonathan Schoonover | Worth County | North Andrew | 11/1/1999 | |
| 24 | 6 | Zach Sharp | Mound City | North Andrew | 11/1/2003 | |
| 24 | 6 | Brayden James Lidgard | West Plains | Parkview | 10/13/2017 | |
| 24 | 6 | Tevin Cameron | Worth County | Sacred Heart | 11/18/2017 | 8-Man |
| 24 | 6 | Colby Stein | Concordia | | 10/11/2019 | |
| 24 | 6 | Luke Anthony Malizzi | Odessa | | 10/11/2019 | |
| 24 | 6 | Travis James Runyan | Mid-Buchanan | Adrian | 11/28/2020 | |
| 24 | 6 | Cameron Jones | Pattonsburg | Rich Hill | 10/2/2020 | |
| 24 | 6 | Dylan Hair | Blair Oaks | Maryville | 12/5/2020 | Class 3 |
| 24 | 6 | Ryder Wilckens-Abney | Concordia | Santa Fe | 9/24/2021 | |
| 24 | 6 | Garren Vroman | Fayette | Salisbury | 10/15/2021 | |
| 24 | 6 | Jobe Bryant | Central (Park Hills) | Central (Park Hills) | 12/1/2023 | |
| 24 | 6 | Jobe Bryant | Central (Park Hills) | Central (Park Hills) | 12/1/2023 | |
| 24 | 6 | Jobe Bryant | Central (Park Hills) | Seneca | 12/1/2023 | |
| 24 | 6 | Brady M Dapkus | Southern Boone | Eldon | 9/29/2023 | |
| 24 | 6 | Austin Evans | Southern Boone | Eldon | 9/29/2023 | |
| 24 | 6 | Jobe Bryant | Central (Park Hills) | Seneca | 12/1/2023 | Class 3 |
| 24 | 6 | Briar McEntire | Archie | Worth County | 11/30/2023 | 8-Man |
| 43 | 5 | Derrick Washington | Raymore-Peculiar | Kirkwood | 11/25/2006 | |
| 43 | 5 | Connor S Basler | Valle Catholic | Penney | 11/28/2015 | |
| 43 | 5 | Colby Stein | Concordia | | 9/21/2018 | |
| 43 | 5 | Evan Urhahn | Kelly | | 10/19/2018 | |
| 43 | 5 | Darrin McElfresh | DeKalb | | 8/30/2019 | |
| 43 | 5 | Troy Brandt | Concordia | | 10/11/2019 | |
| 43 | 5 | Cameron Jones | Pattonsburg | Schuyler County | 9/4/2020 | |
| 43 | 5 | Garren Vroman | Fayette | Paris | 10/1/2021 | |
| 43 | 5 | Garren Vroman | Fayette | Slater | 9/10/2021 | |
| 43 | 5 | Jeremiyah Love | Christian Brothers College | Lee's Summit North | 11/26/2022 | Class 6 |
| 43 | 5 | Logan Horton | Chaffee | Veritas Christian HS | 10/11/2024 | |
| 43 | 5 | Tristan Leeper | Archie | North Shelby | 12/7/2024 | 8-Man |
| 43 | 5 | Jonathan Moore | Lutheran North | Festus | 12/6/2024 | Class 4 |